PMID: 11315624Apr 24, 2001Paper

Nasal CD56 positive small round cell tumors. Differential diagnosis of hematological, neurogenic, and myogenic neoplasms

Virchows Archiv : an International Journal of Pathology
Q LiuM Kikuchi

Abstract

CD56-positive nasal and nasal-type natural killer (NK)/T-cell lymphoma is now a well-defined disease entity. Rare cases of blastic NK-cell lymphoma positive for CD56 have been recently reported. However, CD56 expression is also identified in several types of non-hematopoietic small round cell tumors in which lymphoma is included as a differential consideration. Here, we present nine cases of CD56+ small round cell tumors of histological origin unrelated to nasal NK/T-cell lymphoma. Eight of the nine cases presented as solid tumors of the sinonasal region. Clinical, histological, ultrastructural, and immunohistochemical examination and gene analysis for T-cell receptor (TcR) and immunoglobulin heavy chain (IgH) genes and in situ hybridization (ISH) for Epstein-Barr virus (EBV) were performed. Two cases presented with features consistent with blastic NK-cell lymphoma or lymphoblastic lymphoma of NK-cell phenotype. These cases showed features of lymphoblastic lymphoma, phenotypes of sCD3-, cCD3+, CD45+, CD56+, TdT+, and human leukocyte antigen (HLA)-DR+, germline of IgH and TcR genes, and EBV negative reactivity. One case had myeloid/NK-precursor acute leukemia/lymphoma with a phenotype of CD13+, CD33+, CD34+, CD56+, and MPO-. Thr...Continue Reading

Citations

Oct 19, 2005·Virchows Archiv : an International Journal of Pathology·Marcus KremerFalko Fend
Dec 17, 2002·Current Opinion in Hematology·Jeffrey B VanDeusen, Michael A Caligiuri
Jun 20, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Yi-Shing Lisa ChengYuk-Kwan Chen
Aug 14, 2008·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Karen MeirOrit Pappo
Apr 16, 2005·Journal of Korean Medical Science·Yoonjung KimYoung H Ko
Feb 3, 2016·Head and Neck Pathology·Alessandro Franchi
Mar 25, 2018·International Journal of Hematology·Yayoi AndoKoji Izutsu

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