Nasal conditioning in perennial allergic rhinitis after nasal allergen challenge

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
A RozsasiTilman Keck

Abstract

Antigen challenge in seasonal allergic rhinitis is considered to be associated with an increased ability of the nose to condition inspired air. In contrast, little is known about air conditioning after antigen challenge in perennial allergic rhinitis (PAR). The aims of this study were to investigate whether antigen challenge in PAR changes nasal air conditioning and to assess the relationship between nasal conditioning and nasal patency and geometry. Nineteen subjects with PAR were enrolled into this study. Measurement of nasal conditioning, active anterior rhinomanometry (AAR), acoustic rhinometry (AR), and clinical symptom evaluation were performed before and after nasal allergen challenge with allergen extracts from house dust mites. Ten and 20 min after nasal allergen challenge, the total water content of the air measured in the nasopharynx and the water gradient across the nose were significantly higher in the nasal cavity in which the allergen extract was sprayed. The temperature on both sides of the nose increased non-significantly after nasal allergen challenge. No correlation to data obtained by AAR, AR, and clinical symptom evaluation after nasal allergen challenge was found. We suggest that an increase in mucosal hum...Continue Reading

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Citations

Apr 18, 2008·Current Allergy and Asthma Reports·Alvaro A Cruz, Alkis Togias
Jul 4, 2006·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Tilman KeckAjnacska Rozsasi
Jun 21, 2008·Respiratory Physiology & Neurobiology·David EladTilman Keck
Jun 5, 2007·The Laryngoscope·Rauf TahamilerSalih Canakcioglu
Oct 1, 2005·Respiration; International Review of Thoracic Diseases·Kristina LienerTilman Keck
Feb 21, 2008·American Journal of Rhinology·Thomas KappeTilman Keck
Oct 27, 2006·American Journal of Rhinology·Tilman KeckTimo Rother
Jul 12, 2007·American Journal of Rhinology·Ajnacska RozsasiTilman Keck

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