Jan 1, 1976

Nasal continuous positive airway pressure. Improvement in arterial oxygenation in hyaline membrane disease

Biology of the Neonate
H HarrisG Cassady

Abstract

Continuous positive airway pressure (CPAP) was employed using nasal prongs in 30 neonates with hyaline membrane disease (HMD). There was a significant improvement in mean PaO2 (from 47 to 80 mmHg;p less than 0.001) with no significant change in PaCO2 or pH within a mean 36 min of therapy. Use of the technique allowed reduction of FiO2 to less than 0.60 in less than 20 h in 18 infants. Infants treated within 24 h of birth had significantly greater improvements in PaO2. Complications were infrequent and only 3 of 30 babies developed a pneumothorax while on nasal CPAP. Only 1 of the 23 survivors required mechanical ventilation in addition to nasal CPAP.

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Mentioned in this Paper

Dioxygen
Alveolar Ventilation Function
Cell Respiration
Oxygen Measurement, Partial Pressure, Arterial
Positive End-Expiratory Pressure
Ventilation, Function (Observable Entity)
Pneumothorax
Respiration
Carbon Dioxide
CENPJ gene

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