Nasal cytological changes as late effects of radiotherapy for nasopharyngeal cancer

American Journal of Rhinology & Allergy
Giuseppe RivaMassimiliano Garzaro

Abstract

Radiation therapy is a cornerstone in nasopharyngeal cancer treatment. However, it can induce acute and long-term adverse effects, such as acute mucositis and late submucosal fibrosis. Late toxicities could not only affect submucosa but also mucosal cells, determining long-term cytological changes. Evaluation of delayed nasal cytological alterations in patients who underwent radiation therapy for nasopharyngeal carcinoma (NPC). In this case-control study, we analyzed 30 healthy subjects and 30 patients treated with chemotherapy and radiotherapy for NPC between 2003 and 2011, with a median follow-up of 59 months. All subjects underwent symptoms anamnestic evaluation (rhinorrea, nasal obstruction), endoscopic fiber optic nasal examination, skin-prick tests, and nasal scraping for cytological exam. A higher percentage of rhinorrhea, nasal obstruction, mucosal hyperemia, and presence of nasopharyngeal secretions at fiber optic endoscopic exam was found in radiated subjects (p < 0.05). Nasal cytology analysis demonstrated a higher percentage of neutrophilic inflammation and squamous cell metaplasia and mucous cell metaplasia in treated patients (p < 0.05). No cytological atypia was seen. No statistically significant correlation betw...Continue Reading

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Citations

Nov 11, 2016·The Annals of Otology, Rhinology, and Laryngology·Giuseppe RivaMassimiliano Garzaro
Jul 25, 2017·International Forum of Allergy & Rhinology·Hannah N KuharPete S Batra
Jan 31, 2018·The Journal of Craniofacial Surgery·Hasan ÇanakciÇağatay Oysu
Jan 18, 2018·American Journal of Rhinology & Allergy·Gwanghui RyuSang Duk Hong
Jan 12, 2019·American Journal of Rhinology & Allergy·Giuseppe RivaGiancarlo Pecorari
Apr 12, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jin-Jie YanHai-Qiang Mai
Jun 2, 2021·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·Francesco BussuGaetano Paludetti

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Methods Mentioned

BETA
dissection
scraping

Software Mentioned

Statistical Package for Social Sciences

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