Nasal high flow does not improve exercise tolerance in COPD patients recovering from acute exacerbation: A randomized crossover study

Respirology : Official Journal of the Asian Pacific Society of Respirology
Guillaume PrieurGregory Reychler

Abstract

We hypothesized that by reducing respiratory work and improving gas exchange, nasal high flow (NHF) would improve exercise tolerance in patients with chronic obstructive pulmonary disease (COPD) following respiratory exacerbation. This was a monocentric, randomized, controlled crossover study. Patients with severe to very severe COPD carried out two high-intensity constant work-rate exercise tests (CWRET) with and without NHF on two consecutive days. The primary outcome was the mean difference in endurance time between both conditions. The secondary aims included vastus lateralis oxygenation (StO2 ), dyspnoea, leg discomfort, maximal inspiratory pressure (MIP), transcutaneous CO2 pressure (PtcCO2 ), respiratory rate (RR), heart rate (HR) and pulsed O2 saturation (SpO2 ), as well as the patients' opinions of the device. A total of 19 patients were included (mean forced expiratory volume in 1 s = 28.7 ± 10.8%, age = 62.1 ± 9.1 years). No significant differences in endurance time during the CWRET were found between the two test conditions (-66.58 (95% CI: -155.9 to 22.7) s, P = 0.12). StO2 , PtCO2 and HR were reduced at the end of the exercise with NHF (-2.1% (95% CI: -4.3 to -0.0); -1.3 mm Hg (95% CI: -2.5 to -0.2); -2.7 bpm (95%...Continue Reading

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Citations

Feb 11, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Don D Sin
Sep 6, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Darren R Mansfield
Dec 29, 2020·Heart & Lung : the Journal of Critical Care·Peng-Lei YangHan-Bing Chen
Mar 6, 2021·Breathe·Rebecca F D'CruzGeorgios Kaltsakas
Mar 12, 2021·Frontiers in Medicine·Konstantinos BitosKonrad E Bloch
Jun 23, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yen-Huey ChenHuang-Pin Wu
Jan 29, 2020·Respiration; International Review of Thoracic Diseases·Judith Elshof, Marieke L Duiverman
Sep 22, 2021·Current Opinion in Supportive and Palliative Care·Maitri MunsifNatasha Smallwood

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