Nasal high-frequency oscillatory ventilation and CO2 removal: A randomized controlled crossover trial

Pediatric Pulmonology
Roberto BottinoGiovanni Vento

Abstract

To compare short-term application of nasal high-frequency oscillatory ventilation (nHFOV) with nasal continuous positive airway pressure (nCPAP). nHFOV improves CO2 removal with respect to nCPAP in preterm infants needing noninvasive respiratory support and persistent oxygen supply after the first 72 h of life. Multicenter non-blinded prospective randomized crossover study. Thirty premature infants from eight tertiary neonatal intensive care units, of mean ± SD 26.4 ± 1.8 weeks of gestational age and 921 ± 177 g of birth weight. Infants were randomly allocated in a 1:1 ratio to receive a starting treatment mode of either nCPAP or nHFOV delivered by the ventilator CNO (Medin, Germany), using short binasal prongs of appropriate size. A crossover design with four 1-h treatment periods was used, such that each infant received both treatments twice. The primary outcome was the mean transcutaneous partial pressure of CO2 (TcCO2 ) value during the 2-h cumulative period of nHFOV compared with the 2-h cumulative period of nCPAP. Significantly lower TcCO2 values were observed during nHFOV compared with nCPAP: 47.5 ± 7.6 versus 49.9 ± 7.2 mmHg, respectively, P = 0.0007. A different TcCO2 behavior was found according to the random sequence...Continue Reading

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Citations

Apr 19, 2019·Pediatric Pulmonology·Christoph SchäferDaniel Klotz
Feb 28, 2019·Pediatric Pulmonology·Richard L Auten
May 28, 2020·Frontiers in Pediatrics·Ibrahim Sammour, Sreenivas Karnati
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