Abstract
To compare short-term application of nasal high-frequency oscillatory ventilation (nHFOV) with nasal continuous positive airway pressure (nCPAP). nHFOV improves CO2 removal with respect to nCPAP in preterm infants needing noninvasive respiratory support and persistent oxygen supply after the first 72 h of life. Multicenter non-blinded prospective randomized crossover study. Thirty premature infants from eight tertiary neonatal intensive care units, of mean ± SD 26.4 ± 1.8 weeks of gestational age and 921 ± 177 g of birth weight. Infants were randomly allocated in a 1:1 ratio to receive a starting treatment mode of either nCPAP or nHFOV delivered by the ventilator CNO (Medin, Germany), using short binasal prongs of appropriate size. A crossover design with four 1-h treatment periods was used, such that each infant received both treatments twice. The primary outcome was the mean transcutaneous partial pressure of CO2 (TcCO2 ) value during the 2-h cumulative period of nHFOV compared with the 2-h cumulative period of nCPAP. Significantly lower TcCO2 values were observed during nHFOV compared with nCPAP: 47.5 ± 7.6 versus 49.9 ± 7.2 mmHg, respectively, P = 0.0007. A different TcCO2 behavior was found according to the random sequence...Continue Reading
References
Sep 1, 1992·Journal of Applied Physiology·K G Henke, C E Sullivan
Nov 3, 1998·Archives of Disease in Childhood. Fetal and Neonatal Edition·M van der HoevenC E Blanco
Jan 1, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·P HummelM G Weiss
Feb 15, 2008·The New England Journal of Medicine·Colin J MorleyUNKNOWN COIN Trial Investigators
Jun 14, 2008·Acta Paediatrica·Tarah T ColaizyJonathan M Klein
Aug 30, 2008·Acta Paediatrica·Waldemar A Carlo
Jul 14, 2010·The Journal of Pediatrics·Anton H van KaamUNKNOWN Neovent Study Group
Nov 3, 2010·Best Practice & Research. Clinical Anaesthesiology·Walid Habre
Oct 26, 2011·Pediatrics·Michael S DunnUNKNOWN Vermont Oxford Network DRM Study Group
Jul 25, 2012·Pediatric Pulmonology·Emidio M SivieriSoraya Abbasi
Dec 22, 2012·Neonatology·Amit MukerjiJaques Belik
Aug 16, 2013·The New England Journal of Medicine·Haresh KirpalaniUNKNOWN NIPPV Study Group
Oct 19, 2013·BMJ : British Medical Journal·Georg M SchmölzerPo-Yin Cheung
Aug 3, 2014·Archives of Disease in Childhood. Fetal and Neonatal Edition·Andrea L LamplandMark C Mammel
Jun 30, 2016·Archives of Disease in Childhood. Fetal and Neonatal Edition·Daniele De Luca, Valentina Dell'Orto
Sep 30, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·A MukerjiV Shah
Jul 4, 2017·Pediatric Pulmonology·Xing-Wang ZhuYuan Shi
Sep 18, 2017·Archives of Disease in Childhood. Fetal and Neonatal Edition·Daniel KlotzHans Fuchs
Citations
Apr 19, 2019·Pediatric Pulmonology·Christoph SchäferDaniel Klotz
Jul 25, 2019·Pediatric Pulmonology·David M RubEric Eichenwald
Apr 27, 2019·BMC Research Notes·Hendrik S FischerChristoph Czernik
Dec 15, 2018·Pediatric Pulmonology·Emidio M SivieriSoraya Abbasi
Mar 17, 2019·Respiratory Research·Jing LiZhiqun Zhang
Feb 28, 2019·Pediatric Pulmonology·Richard L Auten
May 28, 2020·Frontiers in Pediatrics·Ibrahim Sammour, Sreenivas Karnati
Oct 9, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ammar Mohammed Haidar Shehadeh
Aug 31, 2019·Pediatric Pulmonology·Emidio M SivieriSoraya Abbasi
Nov 12, 2020·Archives of Disease in Childhood. Fetal and Neonatal Edition·Dany E WeiszUNKNOWN Canadian Neonatal Network Investigators
Nov 11, 2020·Pediatric Pulmonology·Corrado MorettiCamilla Gizzi
Oct 24, 2020·AJP Reports·Pio Liberatore, Gianfranco Maffei
Oct 24, 2020·American Journal of Respiratory and Critical Care Medicine·Vincent D GaertnerChristoph M Rüegger
Apr 24, 2021·European Journal of Pediatrics·Soutrik SethAvijit Hazra
Apr 25, 2021·The Journal of Pediatrics·Leeann R PavlekCarl H Backes
Jul 14, 2021·European Journal of Pediatrics·Jie LiYuan Shi
Apr 12, 2019·Neonatology·David G SweetHenry L Halliday
Oct 7, 2021·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Minqiao JianCaisheng Liu