Abstract
Nasal inverted papilloma is a rare benign tumor of epithelial origin with aggressive evolution, bone destruction, recurrence, and malignant transformation. Msx2 is a homeobox gene implicated in organ development, bone metabolism, and tumorigenesis. Using reverse transcriptase-polymerase chain reaction and immunohistochemistry, Msx2 expression was examined in nasal inverted papilloma and in nontumorigenic tissue counterparts. For the first time, Msx2 was detected in all inverted papillomas but not in the nasal polyps or in the normal mucosa. The protein expression level was directly and significantly associated with tumor recurrence. Furthermore, Msx2 was associated with bone resorption markers receptor activator of nuclear factor-kappa B ligand and tartrate-resistant acid phosphatase, suggesting a role in osteolysis. In conclusion, Msx2 expression may represent a useful prognostic marker in inverted papilloma.
References
Feb 28, 1989·Biochemical and Biophysical Research Communications·M ZaidiI MacIntyre
Apr 1, 1971·The Annals of Otology, Rhinology, and Laryngology·V J Hyams
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·Y H LiuR E Maxson
Nov 5, 1993·Cell·E W JabsJ B Mulliken
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·H ZhangC Abate-Shen
Apr 1, 1996·Mechanisms of Development·K M CatronC Abate-Shen
Dec 31, 1997·The Journal of Biological Chemistry·E P NewberryD A Towler
May 20, 1998·The Laryngoscope·C GuichardA Coste
Sep 19, 1998·Endocrine·J R WerkmeisterT J Rosol
Sep 1, 1999·The Journal of Investigative Dermatology·T X JiangC M Chuong
Nov 24, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S HopyanJ S Wunder
Dec 10, 1999·Pediatric Research·D M McCoyR K Mallampalli
Mar 31, 2000·Nature Genetics·A O WilkieR E Maxson
Mar 31, 2000·Nature Genetics·I SatokataR Maas
Apr 25, 2000·Gene·A J Bendall, C Abate-Shen
Nov 4, 2000·Bone·G W OddieD A Hume
Sep 25, 2001·The Laryngoscope·M A ThorpS L Sellars
Oct 31, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·K ShirakabeE Nishida
Nov 7, 2001·The American Journal of Pathology·S L HolleyP R Hoban
Dec 6, 2002·Development·Liang MaCheng-Ming Chuong
Jan 28, 2004·Human Pathology·Silvana PapagerakisAriane Berdal
Apr 3, 2004·Molecular and Cellular Biology·Tatsuya YoshizawaHiroyuki Kawashima
Jun 11, 2005·Cancer Investigation·T MalewskiK Augustowska
Jan 24, 2006·Acta Oto-laryngologica·Hideaki KatoriMamoru Tsukuda
Citations
Jul 3, 2010·Head and Neck Pathology·Ann Sandison
Oct 19, 2010·Journal of Oncology·Claudia D Andl
Oct 16, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Blandine Ruhin-PoncetAriane Berdal
Nov 28, 2013·PloS One·Beatriz CastanedaFrédéric Lézot
Apr 1, 2012·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·J Godfrey Heathcote
Jan 20, 2011·American Journal of Rhinology & Allergy·Il Joon MoonChae-Seo Rhee