PMID: 9184975May 4, 1997Paper

Nasal mucociliary transport and ciliary ultrastructure in cystic fibrosis. A comparative study with healthy volunteers

International Journal of Pediatric Otorhinolaryngology
M ArmengotJ Basterra

Abstract

Cystic fibrosis (CF) is a deadly hereditary disease that produces an abnormally thick, viscous and abundant secretion in the respiratory tract. This secretion in turn leads to the development of recurrent respiratory infections and irreversible lung damage. We have studied nasal mucociliary transport by means of an isotopic technique in 12 patients with CF and in 12 healthy volunteers. Nasal mucociliary transport was repeated at 12-18 months in the patients. In five randomly selected patients ciliary ultrastructure was studied. The velocity of nasal mucociliary transport was significantly slower than in healthy persons (P < 0.001) and no significant differences were observed in both studies (P < 0.05). No significant differences were either observed in the CF group between the homo- and heterozygotes (P < 0.5), or in those six patients infected by Pseudomonas aeruginosa (P < 0.05). Ciliary ultrastructure was normal in one patient. In another patient the sample showed no cilia, while the remaining three exhibited changes similar to those observed in chronic respiratory infections: supernumerary peripheral tubules, ciliary disorientation and ciliary complexes.

References

Jan 1, 1976·Archives of Disease in Childhood·D B YeatesN Aspin
Sep 1, 1991·International Journal of Pediatric Otorhinolaryngology·M Armengot, J Basterra
Mar 2, 1989·Nature·M Farrall, P J Scambler
Jan 1, 1986·Tissue & Cell·M C Holley, B A Afzelius
Mar 29, 1973·The New England Journal of Medicine·J SanchisM Newhouse
Dec 1, 1982·European Journal of Pediatrics·C W ChowL M Taussig
Mar 1, 1995·American Journal of Respiratory and Critical Care Medicine·C F RaynerR Wilson
Aug 14, 2001·Clinics in Perinatology·L P Shulman, S Elias

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Citations

Dec 17, 2005·American Journal of Respiratory Cell and Molecular Biology·Stephen T BallardCharles R Hamm
Dec 3, 2013·International Journal of Pharmaceutics·Yi-Bo WangRobert O Williams
Apr 2, 2013·The Journal of Allergy and Clinical Immunology·Joy HsuJayant M Pinto
Mar 29, 2002·Pediatric Pulmonology·Michael Robinson, Peter T B Bye
Jun 12, 2010·American Journal of Rhinology & Allergy·Miguel ArmengotJulio Cortijo
Oct 16, 2004·Expert Review of Anti-infective Therapy·Sang Sun Yoon, Daniel J Hassett
Feb 27, 2017·International Forum of Allergy & Rhinology·Benjamin P HullRakesh K Chandra
Jul 27, 2018·Current Allergy and Asthma Reports·Wei-Jie GuanDe Yun Wang
Nov 15, 2016·Current Opinion in Otolaryngology & Head and Neck Surgery·Frederick Yoo, Jeffrey D Suh

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