Nasal mucosa derived-mesenchymal stem cells from mice reduce inflammation via modulating immune responses

PloS One
Chen YangChunquan Zheng

Abstract

Mesenchymal stem cells (MSCs) have arisen the attention to be a new attractive therapeutic tool treating autoimmune diseases such as allergic rhinitis (AR). AR is a chronic reversible allergic inflammation caused by the excessive activation of T-helper 2 (Th2) cells. Recently, MSCs have been proposed as a new therapy of AR as it can suppress some cytokines to control allogeneic Th2 response and functions. However, how MSCs function to reduce inflammation remains unclear. In this study, we aimed to investigate the role of ectomesenchymal stem cells (ECTO-MSCs) derived from nasal mucosa in eosinophilic inflammation and how it affects some immunoglobulins and cytokines. We used ovalbumin (OVA) as a sensitizer to induce nasal inflammation in mice by both injection and inhalation. In order to obtain deeper insights into the influences of ECTO-MSCs on nasal inflammation, the migration of ECTO-MSCs was assessed, the numbers of eosinophils and sneezing were counted, and several immunoglobulins and cytokines were measured. Here we show the ECTO-MSCs are able to migrate to inflammation site via tail vein injection. Eosinophils and sneezing were suppressed by ECTO-MSCs. Interestingly, IgE, interleukin (IL)-4, IL-5 and IL-10 secreted by Th...Continue Reading

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Citations

Nov 25, 2016·Experimental and Therapeutic Medicine·Jianxia HuHong Xu
Feb 20, 2019·International Journal of Molecular Sciences·Nesrine EbrahimAhmed Refae
Jun 27, 2020·Stem Cells International·Liwei SunDongdong Zhu
Feb 6, 2018·Allergologia et immunopathologia·A Golshiri-IsfahaniM K Arababadi
Aug 26, 2019·Allergology International : Official Journal of the Japanese Society of Allergology·He LiWenru Su
Jun 24, 2020·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Ece Çerçi, Hatice Erdost

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Methods Mentioned

BETA
pharmacotherapy
fluorescence microscopy
light microscopy
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SPSS

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