Nasal neutrophil activity and mucinous secretory responsiveness in COPD

Clinical Physiology and Functional Imaging
Ulf NihlénL Greiff

Abstract

Patients with chronic obstructive pulmonary disease (COPD) frequently report nasal symptoms. In the present study, we have examined whether or not COPD is associated with any nasal inflammation. Plasma exudation evoked by histamine challenges has been employed to improve the recovery of inflammatory indices in nasal lavage fluids. In 23 COPD-patients and 26 healthy subjects, all without history or signs of allergic rhinitis, nasal polyposis, or chronic rhinosinusitis, nasal saline-lavages were performed with and without histamine. alpha2-Macroglobulin, fucose, eosinophil cationic protein (ECP) and myeloperoxidase (MPO) were determined as indices of plasma exudation, mucinous secretion, eosinophil activity and neutrophil activity, respectively. The difference in MPO-levels between the histamine and the saline lavage was greater in COPD patients compared with healthy subjects (P<0.05). Also, COPD patients reporting nasal symptoms presented an increase in MPO at histamine challenge (P<0.05, cf. saline) and greater differences in MPO and fucose, respectively, between the histamine and the saline lavage (P<0.05, cf. patients without symptoms). We conclude that COPD is not associated with any marked nasal inflammation. However, our o...Continue Reading

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Citations

Sep 24, 2005·American Journal of Respiratory and Critical Care Medicine·John R HurstJadwiga A Wedzicha
Jul 16, 2010·International Journal of Chronic Obstructive Pulmonary Disease·Violetta M PiotrowskaAdam Antczak
May 29, 2007·COPD·Jung-Soo Kim, Bruce K Rubin
Mar 12, 2008·Clinical Physiology and Functional Imaging·Ulf NihlénLennart Greiff
Jul 14, 2006·Clinical Physiology and Functional Imaging·John R HurstJadwiga A Wedzicha
Apr 21, 2010·PloS One·Malin InghammarArne Egesten
May 16, 2015·American Journal of Rhinology & Allergy·Chen-Yu ChienCharles Tzu-Chi Lee
Feb 28, 2008·Current Opinion in Pulmonary Medicine·Jung-Soo Kim, Bruce K Rubin

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