PMID: 6402202Feb 26, 1983Paper

Nasal nicotine solution: a potential aid to giving up smoking?

British Medical Journal
M A RussellO Ferno

Abstract

A nasal solution was developed containing 2 mg nicotine for use as a kind of liquid snuff. Its absorption was studied in three subjects. An average peak of plasma nicotine concentrations of 86.9 nmol/l (14.1 ng/ml) was reached seven and a half minutes after taking the solution. This compared with an average peak of 158.4 nmol/l (25.7 ng/ml) one and a half minutes after completing (but seven and a half minutes after starting) a middle tar cigarette (1.4 mg nicotine) and an average peak of 52.4 nmol/l (8.5 ng/ml) after chewing nicotine gum (2 mg nicotine) for 30 minutes. The more rapid and efficient absorption of nicotine from the nasal nicotine solution than from nicotine chewing gum suggests that it might prove a useful aid to giving up smoking. Nasal nicotine solution might be particularly useful in smokers for whom the gum is less suitable on account of dentures or peptic ulcers or who experience nausea and dyspeptic symptoms from the gum.

References

Mar 1, 1980·Lancet·M A RussellC Feyerabend
Mar 1, 1980·The Journal of Pharmacy and Pharmacology·C Feyerabend, M A Russell
Sep 26, 1981·British Medical Journal·M A RussellC Feyerabend
Aug 21, 1982·British Medical Journal·M J JarvisC Feyerabend

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Citations

Jan 1, 1991·European Journal of Clinical Pharmacology·C J JohanssonP O Gunnarsson
Jan 1, 1992·Psychopharmacology·G SutherlandO Ferno
Mar 1, 1988·Medical & Biological Engineering & Computing·J E Lux, R C Frecker
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Oct 1, 1987·Pharmacology, Biochemistry, and Behavior·J E Rose, F Behm
Feb 1, 1991·Pharmacology, Biochemistry, and Behavior·R West, S Hack
Dec 14, 1985·Lancet·M A RussellC Feyerabend
Feb 21, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yu Hui ChengL Illum
Oct 27, 1998·Clinics in Dermatology·A V Gore, Y W Chien
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May 16, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Helena DigardAudrey Richter
Oct 1, 1994·Addiction·O Fernö
Jun 1, 1990·The Journal of Pharmacy and Pharmacology·C Feyerabend, M A Russell
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Apr 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·N SuzukiS Kitamura
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Sep 1, 1987·British Journal of Addiction·M J JarvisC Feyerabend
Jun 1, 1985·British Journal of Addiction·M A RussellM J Jarvis
Jun 1, 1984·British Journal of Addiction·R J WestC Feyerabend

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