Nasal nitric oxide for early diagnosis of primary ciliary dyskinesia: practical issues in children

Respiratory Medicine
G L PiacentiniA L Boner

Abstract

Primary ciliary dyskinesia (PCD) is a genetic disease characterized by abnormally beating cilia. In these patients, levels of nasal nitric oxide (nNO) are lower than those observed in healthy subjects. We identify the nNO levels in healthy pre-school uncooperative children and in PCD patients, in order the application of nNO measurement in the early identification of young children with PCD. We measured nNO in 77 healthy children (50 uncooperative and 27 cooperative) and in 10 PCD patients. Fifteen cooperative healthy children were also asked to perform an uncooperative test. PCD patients presented low nNO levels (29.7+/-5.7 ppb) compared to those observed in healthy children (358.8+/-35.2 ppb; p<0.05). nNO levels were increased in healthy cooperative children (650+/-60.6 ppb; p<0.05) as compared to those uncooperative aging more than 6 month (309.1+/-45.9 ppb; p<0.05) or less (128.1+/-16.2 ppb; p<0.05). Twenty-four uncooperative children with nNO values < or = 200 ppb performed a second evaluation at least 6 months later and mean levels increased from 104.7+/-10.5 ppb to 169.9+/-19.6 ppb (p<0.05). In the 15 collaborative children nNO levels were higher during the breath holding manoeuvre (687.7+/-96.9 ppb) than during the tida...Continue Reading

References

Dec 1, 1996·The European Respiratory Journal·J DötschP G Kühl
Oct 1, 1996·Archives of Disease in Childhood·I M Balfour-LynnR Dinwiddie
Oct 1, 1996·Archives of Disease in Childhood·J O LundbergK Alving
Dec 5, 1997·The European Respiratory Journal·A Ellerman, H Bisgaard
Dec 24, 1997·Acta Paediatrica·U SchedinC Frostell
Nov 17, 1998·The European Respiratory Journal·A BushJ O Warner
Dec 29, 1998·Respiration Physiology·A ArtlichL Gortner
Aug 13, 1999·The European Respiratory Journal·B KaradagA Bush
Mar 29, 2000·Pediatric Pulmonology·M Meeks, A Bush
Jul 14, 2000·Acta Oto-laryngologica·J PalmJ Lundberg
Dec 9, 2000·American Journal of Respiratory and Critical Care Medicine·H NakanoJ Iwamoto
May 8, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D ColantonioG K Scadding
Feb 7, 2003·The European Respiratory Journal·T WodehouseP J Cole
Apr 19, 2003·American Journal of Respiratory and Critical Care Medicine·Maria DejaKlaus Lewandowski
Apr 23, 2003·Early Human Development·Olivia WilliamsAnne Greenough
Nov 2, 2004·The European Respiratory Journal·E BaraldiF Zacchello
Apr 9, 2005·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN European Respiratory Society
Jul 26, 2005·Archives of Disease in Childhood·A Bush
Aug 6, 2005·American Journal of Respiratory and Critical Care Medicine·Jon O Lundberg
Sep 2, 2005·The European Respiratory Journal·V M D StrubenJ C de Jongste
Dec 15, 2005·Pediatric Pulmonology·Bruno MahutChristophe Delclaux
Mar 16, 2007·Chest·Massimo PifferiAttilio L Boner

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Citations

Dec 25, 2013·Annals of the American Thoracic Society·Jane S Lucas, Woolf T Walker
Feb 7, 2014·Annals of the American Thoracic Society·Raymond H KimSharon D Dell
Sep 29, 2011·Revue des maladies respiratoires·J BeucherE Deneuville
Mar 21, 2009·Current Opinion in Pediatrics·Margaret W LeighMichael R Knowles
Jul 17, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Margaret W LeighMaimoona A Zariwala
Sep 20, 2011·Proceedings of the American Thoracic Society·Scott D SagelSharon D Dell
Aug 27, 2014·Pediatric Pulmonology·Angelo MannaFrancesca Santamaria
Mar 4, 2015·Pediatric Pulmonology·Nicole BeydonMuriel Le Bourgeois
Mar 26, 2010·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·A Moreno GaldóR Busquets Monge
Oct 19, 2011·Pediatric Pulmonology·Marco MaglioneFrancesca Santamaria
Nov 16, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·G L PiacentiniA L Boner
Feb 11, 2015·Annual Review of Physiology·Nadzeya V Marozkina, Benjamin Gaston
Jun 16, 2018·American Journal of Respiratory and Critical Care Medicine·Adam J ShapiroUNKNOWN American Thoracic Society Assembly on Pediatrics
Oct 18, 2014·The European Respiratory Journal·Samuel A CollinsJane S A Lucas
Jan 18, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Nisreen RummanJane S Lucas
Jul 30, 2019·Minerva pediatrica·Maria Grazia PappalardoSalvatore Leonardi

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