Nasal NK-cell lymphoma followed by relapse in the uterine cervix

Leukemia & Lymphoma
Takayuki MuraseTadaaki Eimoto

Abstract

We report a case of nasal natural killer (NK)-cell lymphoma in a 51-year-old Japanese woman who showed a later relapse in the uterine cervix. The nasal NK-cell lymphoma regressed after local radiation therapy. Six months after the diagnosis while the patient was being treated with chemotherapy for a subclinical tumor, a mass lesion of the uterine cervix was noticed by follow-up computed tomography. Giemsa-stained vaginal smear showed lymphoid tumor cells with large azurophilic granules, leading to a rapid diagnosis of cervical involvement by NK-cell lymphoma. The chemotherapy regimens were immediately changed, but the patient died 2 months after the relapse with an overall survival of 8 months. This case may be of value in elucidating the biological behavior and natural history of NK-cell lymphoma.

References

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Citations

Nov 25, 2005·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Anand S Lagoo, Stanley J Robboy
Jan 21, 2006·Gynecologic and Obstetric Investigation·Juliane BrieseHans-Peter Horny
Feb 13, 2016·Diagnostic Cytopathology·Makiko OmoriShuji Hirata

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