PMID: 9438057Jan 23, 1998Paper

Nasal obstruction improvement induced by topical furosemide in subjects affected by perennial nonallergic rhinitis

American Journal of Rhinology
Simonetta MasieriF Filiaci

Abstract

Inhaled furosemide decreases bronchial response to several physical and chemical irritants. To evaluate the effect of topical furosemide on nasal resistance in patients affected by perennial nonallergic rhinitis, we studied 12 patients. This diagnosis of perennial nonallergic rhinitis was based on the history of rhinorrhea, sneezing, and nasal obstruction, on anterior rhinoscopy and endoscopy, on negative allergic tests, and on the absence of eosinophilia in nasal secretion. The study was performed on two nonconsecutive days. On the first day, one puff (100 microliters) of 0.9% saline was sprayed into both nostrils and nasal resistance was measured by anterior rhinomanometry before the puff and 15 and 30 minutes later. On the second day, one puff (100 microliters) of a solution of furosemide (10 mg/mL) was sprayed into both nostrils and nasal resistance was measured before the puff and 15, 30, 45, 60, 90, 120, and 180 minutes later. Initial nasal resistance was abnormally high in all patients on both days. A slight but significant increase was observed after spraying isotonic saline (base: 1.38 +/- .69; 15 minutes: 1.47 +/- 0.72; 30 minutes: 1.44 +/- 0.73); by contrast a marked decrease was observed after spraying the furosemid...Continue Reading

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Citations

May 9, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·D Robert WebbCindy K Cook
Jul 7, 2001·American Journal of Therapeutics·J Prandota
Jul 10, 2007·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Srdjan Ante AnzicLivije Kalogjera
Jan 19, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R J SalibP H Howarth
Apr 22, 2006·Journal of Applied Physiology·Stuart B Mazzone, Alice E McGovern

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