Nasal OEC transplantation promotes respiratory recovery in a subchronic rat model of cervical spinal cord contusion

Experimental Neurology
J C StamegnaV Matarazzo

Abstract

Engraftment of nasal olfactory ensheathing cells (OEC) is considered as a promising therapeutic strategy for spinal cord repair and one clinical trial has already been initiated. However, while the vast majority of fundamental studies were focused on the recovery of locomotor function, the efficiency of this cellular tool for repairing respiratory motor dysfunction, which affects more than half of paraplegic/tetraplegic patients, remains unknown. Using a rat model that mimics the mechanisms encountered after a cervical contusion that induces a persistent hemi-diaphragmatic paralysis, we assessed the therapeutic efficiency of a delayed transplantation (2 weeks post-contusion) of nasal OECs within the injured spinal cord. Functional recovery was quantified with respiratory behavior tests, diaphragmatic electromyography and neuro-electrophysiological recording of the phrenic motoneurons while axogenesis was evaluated using immunohistochemistry. We show that 3 months post-transplantation, nasal OECs improve i) breathing movements, ii) activities of the ipsilateral diaphragm and corresponding phrenic nerve, and iii) axonal sprouting in the injury site. We also demonstrate that this functional partial recovery is mediated by the rest...Continue Reading

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Citations

Jan 17, 2015·Indian Journal of Orthopaedics·Harvinder Singh Chhabra, Kanchan Sarda
May 17, 2015·Experimental Neurology·Kevin C Hoy, Warren J Alilain
Mar 18, 2015·Reviews in the Neurosciences·Da Duan, Ming Lu
Oct 27, 2010·Experimental Neurology·Yu JiaoPetri Olivius
Mar 14, 2013·BioMed Research International·Jun Li, Guilherme Lepski
Jan 24, 2018·Journal of Neurotrauma·Jean-Claude StamegnaFrançois S Roman
Dec 20, 2018·Journal of Neurotrauma·Philippa Mary Warren, Warren Joseph Alilain

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