Nasal scraping in diagnosing ciliary dyskinesia

American Journal of Rhinology
Giuseppi CarusoMaria M de Santi

Abstract

Primary ciliary dyskinesia (PCD) is a congenital, clinically and ultrastructurally heterogeneous disease caused by abnormal structure and/or function of cilia. Kartagener's syndrome is one subgroup of PCD. Acquired ciliary dyskinesia is frequent, generally being associated with or following respiratory tract infections. From January 2003 to April 2006, nasal mucociliary transport time was measured in 64 patients and specimens obtained by nasal scraping were examined by transmission electron microscope (TEM). The 64 nasal scrapings led to the diagnosis of 11 (17.2%) cases of PCD and 51 (79.7%) cases of secondary ciliary disorder. In two cases (3.1%) no clear diagnosis was possible. Nasal scraping is an easy, cheap, and efficient tool for detecting ciliary abnormalities by TEM and for distinguishing acquired and congenital modifications.

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Citations

Mar 1, 2012·International Journal of Legal Medicine·Maria Carolina RomanelliBiagio Solarino
Feb 2, 2011·Pediatric Pulmonology·J Tod OlinUNKNOWN Genetic Disorders of Mucociliary Clearance Consortium
Apr 18, 2015·International Forum of Allergy & Rhinology·Filiz AydoğanEthem Erdal Samim
Mar 25, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M GelardiG Passalacqua
Jun 18, 2016·The Laryngoscope·Eelam A AdilMichael J Cunningham
Jan 13, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Giulio PagliucaAndrea Gallo
Feb 11, 2016·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Chiara RosatoAndrea Gallo
Jun 12, 2010·American Journal of Rhinology & Allergy·Miguel ArmengotJulio Cortijo
Jun 16, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E HefflerM Gelardi
Dec 17, 2016·The World Allergy Organization Journal·Matteo GelardiGiovanni Passalacqua

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