Nascent blood vessels in the skin arise from nestin-expressing hair-follicle cells

Proceedings of the National Academy of Sciences of the United States of America
Yasuyuki AmohRobert M Hoffman

Abstract

Besides forming hair shafts, the highly organized, metabolically vigorous hair follicle plays several crucial roles in skin architecture. The follicle contains a distinct population of presumptive follicular stem cells that express nestin, also a marker for neural stem cells. These nestin-expressing follicle cells are located principally in the follicular bulge region. Nestin-driven GFP (ND-GFP), transfected into mice, principally labels cells in the bulge region, which is consistent with the cells' being the stem cells of the hair follicle. We report here that ND-GFP also labels developing skin blood vessels that appear to originate from hair follicles and form a follicle-linking network. This is seen most clearly by transplanting ND-GFP-labeled vibrissa (whisker) hair follicles to unlabeled nude mice. New vessels grow from the transplanted follicle, and these vessels increase when the local recipient skin is wounded. The ND-GFP-expressing structures are blood vessels, because they display the characteristic endothelial-cell-specific markers CD31 and von Willebrand factor. This model displays very early events in skin angiogenesis and can serve for rapid antiangiogenesis drug screening.

References

Jan 26, 1999·Developmental Biology·P J Yaworsky, C Kappen
Jan 14, 2000·Nature Biotechnology·R M Hoffman
Apr 20, 2000·The Journal of Investigative Dermatology·L MecklenburgR Paus
Feb 22, 2001·The Journal of Clinical Investigation·K YanoM Detmar
Sep 5, 2001·Nature Cell Biology·J G TomaF D Miller
Dec 12, 2001·Seminars in Oncology·J Folkman
Nov 5, 2002·Nature Reviews. Cancer·Shahin RafiiBeate Heissig
Aug 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Lingna LiRobert M Hoffman
Dec 13, 2003·Science·Tudorita TumbarElaine Fuchs
Mar 17, 2004·Nature Biotechnology·Rebecca J MorrisGeorge Cotsarelis

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Citations

Jun 16, 2012·Archives of Dermatological Research·Francesco D'AgostiniSilvio De Flora
Aug 5, 2010·Medical Molecular Morphology·Yasuyuki AmohRobert M Hoffman
Aug 16, 2011·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Hajime InoueNorio Kumagai
Feb 25, 2011·International Journal of Clinical Oncology·Norio YamamotoRobert M Hoffman
May 8, 2010·Angiogenesis·T J A SnoeksE L Kaijzel
Sep 13, 2008·Clinical & Experimental Metastasis·Robert M Hoffman
Apr 5, 2007·Nature Protocols·Robert M Hoffman, Meng Yang
Oct 1, 2005·Nature Reviews. Cancer·Robert M Hoffman
Sep 26, 2013·Nature Reviews. Molecular Cell Biology·Guiomar Solanas, Salvador Aznar Benitah
Jan 7, 2006·Gene Therapy·Y Sugiyama-NakagiriH Shimizu
May 11, 2012·Stem Cells and Development·Emma BellNicholas Hole
Feb 12, 2013·Tissue Engineering. Part a·Ken MatsudaRodney J Dilley
Nov 20, 2012·Tissue Engineering. Part B, Reviews·Panagiotis Mistriotis, Stelios T Andreadis
May 13, 2008·Cardiovascular Research·Dimitri Scholz, Suleyman Ergun
Feb 7, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Karl J L FernandesFreda D Miller
Apr 11, 2006·The Journal of Clinical Investigation·Marcos G GrisottoSergio A Lira
Nov 23, 2013·PloS One·Hiroyuki KishimotoRobert M Hoffman
Jan 1, 2009·Critical Reviews in Biomedical Engineering·Ming ChenFrancois Berthiaume
Mar 30, 2007·BioTechniques·Jihui ZhangA Joseph D'Ercole
Oct 25, 2008·Regenerative Medicine·Tomasz Drewa
Jan 29, 2011·World Journal of Gastroenterology : WJG·Toshiyuki IshiwataZenya Naito
Jan 18, 2013·World Journal of Gastroenterology : WJG·Yoko MatsudaToshiyuki Ishiwata
May 15, 2012·International Journal of Oncology·Atsuki SatoZenya Naito
Jul 28, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jozef SkardaJuri Kopolovic
Sep 1, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Klaus Sellheyer
Apr 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yasuyuki AmohRobert M Hoffman
Nov 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yasuyuki AmohRobert M Hoffman
Sep 24, 2005·Journal of Biomedical Optics·Robert M Hoffman
Dec 1, 2004·The Journal of Cell Biology·Michail S DavidoffDieter Müller
Feb 21, 2007·Expert Opinion on Biological Therapy·Robert M Hoffman
Oct 20, 2006·Expert Opinion on Biological Therapy·Stelios T Andreadis
Apr 28, 2006·Expert Opinion on Drug Delivery·Robert M Hoffman
Jun 12, 2014·Journal of Cellular Physiology·Andréanne ChabotAngelino Calderone
Dec 31, 2005·The Journal of Investigative Dermatology. Symposium Proceedings·Jürgen LademannUlrike Blume-Peytavi
Jun 29, 2012·Acta histochemica·Mugurel Constantin RusuDumitru Păduraru
Jun 26, 2009·The Journal of Investigative Dermatology·Stephan TiedeRalf Paus
Jul 15, 2006·The Journal of Investigative Dermatology·Yasuyuki AmohRobert M Hoffman
Apr 6, 2013·The Journal of Investigative Dermatology·Ying XiaoIsaac Brownell

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