Nasopharyngeal biofilm-producing otopathogens in children with nonsevere recurrent acute otitis media

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Sara TorrettaSusanna Esposito

Abstract

Bacterial biofilms have been detected in biopsies of the adenoid and middle ear mucosa of otitis-prone children and children with chronic middle otitis media. However, the invasiveness of biopsy makes it unsuitable for routine clinical practice, especially in pediatrics. This study aimed to investigate nasopharyngeal biofilm-producing otopathogens (BPOs) of nasopharyngeal swabs (NPS) in children with a history of nonsevere recurrent acute otitis media (RAOM) and healthy controls. A cross-sectional study with planned data collection. University of Milan. Transoral NPS were taken from infants and children aged 10 months to 11 years with nonsevere RAOM or healthy controls without adenoid hypertrophy. Nasopharyngeal colonization by otopathogens was assessed by means of microbiological cultures and standard bacterial identification, as well as nasopharyngeal BPOs by means of spectrophotometric analysis. The study involved 113 children (56.6% males; median age 40 months; range, 10-132 months): 58 with a history of nonsevere RAOM (51.3%) and 55 controls (48.7%). Otopathogens were significantly more frequently detected in the RAOM group (24/58, 41.4%) than in controls (8/55, 14.5%; P = .003); the main pathogens were respectively Haemop...Continue Reading

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Citations

Jan 28, 2014·The Journal of Infectious Diseases·Laura R MarksAnders P Hakansson
Jun 4, 2013·International Journal of Pediatric Otorhinolaryngology·Sara TorrettaLorenzo Pignataro
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Jun 20, 2019·Frontiers in Pediatrics·Sara TorrettaPaola Marchisio
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Methods Mentioned

BETA
biopsies
biopsy
scanning electron microscopy

Software Mentioned

STATA

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