Nasopharyngeal carcinoma

Lancet
Melvin L K ChuaAnthony T C Chan

Abstract

Epidemiological trends during the past decade suggest that although incidence of nasopharyngeal carcinoma is gradually declining, even in endemic regions, mortality from the disease has fallen substantially. This finding is probably a result of a combination of lifestyle modification, population screening coupled with better imaging, advances in radiotherapy, and effective systemic agents. In particular, intensity-modulated radiotherapy has driven the improvement in tumour control and reduction in toxic effects in survivors. Clinical use of Epstein-Barr virus (EBV) as a surrogate biomarker in nasopharyngeal carcinoma continues to increase, with quantitative assessment of circulating EBV DNA used for population screening, prognostication, and disease surveillance. Randomised trials are investigating the role of EBV DNA in stratification of patients for treatment intensification and deintensification. Among the exciting developments in nasopharyngeal carcinoma, vascular endothelial growth factor inhibition and novel immunotherapies targeted at immune checkpoint and EBV-specific tumour antigens offer promising alternatives to patients with metastatic disease.

References

Feb 28, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K F FooD Machin
Feb 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jin-Ching LinWen-Yi Wang
Sep 1, 2004·International Journal of Radiation Oncology, Biology, Physics·Jin-Ching LinAndy C Lin
Oct 29, 2004·Nature Reviews. Cancer·Lawrence S Young, Alan B Rickinson
Apr 6, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anthony T C ChanAlex Y Chang
Jun 14, 2005·Lancet·William I Wei, Jonathan S T Sham
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Quynh-Thu LeJames L Zehnder
Sep 20, 2005·International Journal of Radiation Oncology, Biology, Physics·Anne W M LeeW M Sze
Mar 9, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jamel DaoudMounir Frikha
Nov 27, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tao LiuGang Huang
Oct 31, 2008·Head & Neck·Melvin Lee Kiang ChuaJohn Seng Hooi Low
Dec 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edwin P HuiAnthony T Chan
Mar 20, 2009·International Journal of Cancer. Journal International Du Cancer·Xiuchan GuoYi Zeng
Apr 24, 2009·International Journal of Radiation Oncology, Biology, Physics·Ivan Weng-Keong ThamJoseph Tien-Seng Wee
Jul 1, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy LeeK Kian Ang
Apr 30, 2010·Chinese Journal of Cancer·Joseph Tien Seng WeeChao-Nan Qian
Jun 29, 2010·Clinical Neurology and Neurosurgery·Chuei-Shiun LiTeng-Yeow Tan
Aug 19, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J NgeowE H Tan
Oct 26, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Anne W M LeeWai-Hon Lau
Nov 30, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Anne W M LeeW H Lau
Jan 29, 2011·Chinese Journal of Cancer·Su-Mei CaoChao-Nan Qian
Feb 15, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E P HuiA T C Chan
Mar 31, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kelly J YuAllan Hildesheim
Jun 15, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael HenkeDietmar Berger

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Citations

Jan 31, 2016·Der Radiologe·M LellW Wuest
Jan 8, 2016·Chinese Journal of Cancer·Sharon Shuxian PohJoseph T S Wee
Mar 1, 2016·HNO·M LellW Wuest
Apr 14, 2016·Trends in Microbiology·Deilson Elgui de OliveiraJoseph S Pagano
Jun 22, 2016·Acta neurologica Belgica·Valerio NardoneLuigi Pirtoli
Jul 19, 2016·The American Journal of Nursing·Janet McKiernan, Bridgette Thom
Oct 19, 2016·Lancet·Melvin L K Chua, Anthony T C Chan
Sep 19, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Melvin Lee Kiang ChuaTerence Wee Kiat Tan
Dec 23, 2016·Chinese Journal of Cancer·Shaodong Hong, Li Zhang
Jan 14, 2017·Acta Oto-laryngologica·Jing ZhangLiangfang Shen
Nov 26, 2016·The British Journal of Radiology·Ren LuoZhixiong Lin
Feb 16, 2017·Clinical and Experimental Pharmacology & Physiology·Wan-Le MaCheng-Xian Guo
May 2, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhen-Zhen ZhangWei Zhang
Jan 26, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J García-LorenzoX León
May 20, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Lei YanJinqiu Gui
Dec 9, 2016·Journal of the National Cancer Institute·Federico RotoloUNKNOWN MAC-NPC Collaborative Group
May 27, 2017·Journal of Bioenergetics and Biomembranes·Zixuan ZhangHao Liu
Jul 20, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yunfei ZhaoHuai Yang
Feb 8, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·You Quan LiMelvin L K Chua
Nov 11, 2017·Journal of Cellular Biochemistry·Baocai LuWenfa Yu
Sep 1, 2017·International Journal of Cancer. Journal International Du Cancer·George FountzilasVassiliki Kotoula
Nov 28, 2017·La Radiologia medica·Meryem AktanMustafa Adli

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