Abstract
Streptococcus pneumoniae (SP) is a leading cause of child mortality globally, killing around half a million children aged 5 years and less per year. Nasopharyngeal carriage of SP is a prerequisite to disease, and the prevalence of colonization reaches 100% within the first few years of life. Serotype prevalence varies geographically, impacting the serotype coverage of pneumococcal vaccines, and serotype prevalence data are limited from large regions of the world, including sub-Saharan Africa. We enrolled 323 unvaccinated children, aged 4-7 years from coastal Kenya and obtained nasopharyngeal swab samples before and after vaccination with the 10-valent pneumococcal vaccine. Vaccination did not reduce the overall prevalence of pneumococcal carriage in our cohort, with 65 (20%) children colonized before vaccination and 63 (19.4%) colonized postvaccination. However, the prevalence of vaccine-included serotypes (vaccine strains) declined from 43% to 19% of positive swabs, whereas non-vaccine serotypes increased from 46% to 73%. This study contributes to the few data available regarding pneumococcal carriage and serotype prevalence in Kenya and is in concordance with reports of dynamic serotype replacement, driven by vaccine pressure.
References
Feb 1, 1987·Journal of Clinical Microbiology·D V LimA F Walsh
Oct 1, 1982·American Journal of Epidemiology·B M GrayH C Dillon
Jan 5, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W P HausdorffG R Siber
Mar 7, 2001·Journal of Clinical Microbiology·K L O'BrienG M Carlone
Mar 5, 2004·The Lancet Infectious Diseases·D BogaertP W M Hermans
Nov 17, 2004·The Pediatric Infectious Disease Journal·Stephen I PeltonColin D Marchant
Oct 9, 2007·The Journal of Infectious Diseases·W P Hanage
Sep 15, 2009·Lancet·Katherine L O'BrienUNKNOWN Hib and Pneumococcal Global Burden of Disease Study Team
Sep 3, 2010·The American Journal of Tropical Medicine and Hygiene·Sanjay Mehta
Oct 20, 2010·PLoS Medicine·Hope L JohnsonKatherine L O'Brien
Oct 3, 2013·PLoS Medicine·Daniel R FeikinUNKNOWN Serotype Replacement Study Group
Jan 28, 2014·PloS One·Effua UsufAndrew Hall
Aug 12, 2014·The Lancet Global Health·Laura L HammittJ Anthony G Scott
Jan 16, 2015·PLoS Neglected Tropical Diseases·Indu MalhotraA Desiree LaBeaud
May 23, 2015·PLoS Neglected Tropical Diseases·A Desiree LaBeaudIndu Malhotra
Mar 18, 2017·Pediatrics·Monica Nayakwadi SingerA Desirée LaBeaud
Citations
Mar 1, 2019·PLoS Neglected Tropical Diseases·Noah D McKittrickA Desirée LaBeaud
Oct 8, 2019·Expert Review of Vaccines·Myint Tin Tin HtarLuis Jodar
Oct 30, 2020·PloS One·Archippe Muhandule BirindwaSusann Skovbjerg
Dec 3, 2020·Tropical Medicine and Infectious Disease·Pacôme MonemoChantal Akoua-Koffi
Nov 25, 2021·Microbiology Spectrum·Emily J CicconeRoss M Boyce