Nasopharyngeal Haemophilus influenzae carriage in Japanese children attending day-care centers

Journal of Clinical Microbiology
Koichi HashidaHideaki Suzuki

Abstract

We conducted a prospective bacteriological survey to investigate antibiotic resistance-related genetic characteristics and the turnover of nasopharyngeal Haemophilus influenzae carriage in healthy children in day-care centers (DCCs). A total of 363 nasopharyngeal mucus samples were collected from children aged 0 to 6 years attending two DCCs in the summer of 2004 (n = 184) and the following winter (n = 179). We obtained 172 H. influenzae isolates and analyzed them by antimicrobial susceptibility testing, PCR for bla(TEM-1) and the penicillin-binding protein (PBP) gene, and pulsed-field gel electrophoresis (PFGE). The overall carriage rate was 47.4% (172/363), and 37.2% of the isolates (64/172) were ampicillin (AMP) resistant. All the resistant isolates had a PBP mutation(s), while only three isolates had TEM-1. The carriage rate was significantly higher in the winter than in the summer (56.4% and 38.6%, respectively), owing to the increase in the numbers of AMP-susceptible H. influenzae isolates in the winter. Children aged < or = 3 years showed a higher rate of carriage of H. influenzae isolates with an AMP resistance gene(s) than those aged > or = 4 years (21.9% and 12.6%, respectively). Forty-two strains with different PFGE ...Continue Reading

References

Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J G Sutcliffe
Jan 1, 1976·Antimicrobial Agents and Chemotherapy·R VegaM J Patterson
Jun 1, 1992·The Journal of Infectious Diseases·G AnianssonC Svanborg
Jan 1, 1991·European Journal of Pediatrics·J P ColletJ P Boissel
Oct 1, 1989·Journal of Clinical Microbiology·S TrottierC Svanborg-Edén
Jan 1, 1988·Infection and Immunity·M B NelsonD Rekosh
Feb 1, 1986·Antimicrobial Agents and Chemotherapy·A A MedeirosG A Jacoby
Aug 1, 1984·Antimicrobial Agents and Chemotherapy·P M MendelmanA L Smith
Aug 1, 1995·Journal of Clinical Microbiology·A SamuelsonA A Lindberg
Sep 1, 1993·American Journal of Public Health·A M Hardy, M G Fowler
Jun 1, 1996·American Journal of Epidemiology·O P AlhoH Oja
Jun 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M UhariM Niemelä
Apr 2, 1999·Pediatrics·P NafstadJ J Jaakkola
Sep 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E VaronR Cohen
Jan 5, 2002·Journal of Medical Microbiology·P MarchisioUNKNOWN Ascanius Project Collaborative Group
Apr 17, 2002·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kimiko UbukataMasatoshi Konno
Jul 26, 2002·Pediatrics International : Official Journal of the Japan Pediatric Society·Kaori MasudaKoichiro Miyata
Jan 9, 2003·Journal of Clinical Microbiology·Isao ManomeMitsuo Kaku
Jan 31, 2003·The Journal of Antimicrobial Chemotherapy·J A García-Rodríguez, M J Fresnadillo Martínez
Apr 4, 2003·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kenji SuzukiShunkichi Baba
Apr 19, 2003·Journal of Clinical Microbiology·Henri DabernatPierre Dellamonica
Apr 23, 2003·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Keiko HasegawaKimiko Ubukata
Jan 27, 2004·The Pediatric Infectious Disease Journal·Rand S FarjoJanet R Gilsdorf
Dec 8, 2004·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Muneki HotomiKinoyori Kuki
Dec 8, 2006·The Journal of Infectious Diseases·Timothy F MurphyAlan J Lesse

❮ Previous
Next ❯

Citations

Nov 5, 2011·The Pediatric Infectious Disease Journal·Sandra K SchumacherStephen I Pelton
Feb 23, 2012·Fukushima Journal of Medical Science·Ayumi MatsumotoMitsuaki Hosoya
Apr 11, 2014·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Carmen PuigCarmen Ardanuy
Apr 29, 2014·International Journal of Medical Microbiology : IJMM·Elżbieta A TrafnyBeata Zielnik-Jurkiewicz
Aug 30, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Robert J Ruben
May 5, 2017·The Pediatric Infectious Disease Journal·María Del Mar Ortiz-RomeroUNKNOWN Collaborators of Study Group of Infectious Diseases in the Child in Cartagena
Apr 18, 2020·The Pediatric Infectious Disease Journal·Nicole L MessinaNigel Curtis
Nov 27, 2009·Journal of Clinical Microbiology·Ankie LebonAlex van Belkum

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.