Nasopharyngeal microbiota in infants with acute otitis media.

The Journal of Infectious Diseases
Markus HiltyKathrin Mühlemann

Abstract

Interspecies interactions of the nasopharyngeal microbiota are likely to be involved in the pathogenesis of acute otitis media (AOM). Capturing the breadth of microbial interactions requires a detailed description of the microbiota during health and AOM. The nasopharyngeal microbiota of 163 infants with (n = 153) or without (n = 10) AOM was characterized using nasopharyngeal swabs and multiplexed pyrosequencing of 16S rRNA. Nasopharyngeal swab specimens were collected during 4 winter seasons from 2004 through 2010 for infants with AOM and during 2010 for controls. Fifty-eight bacterial families were identified, of which Moraxellaceae, Streptococcaceae, and Pasteurellaceae were the most frequent. Commensal families were less prevalent in infants with AOM than in controls. In infants with AOM, prior exposure to antimicrobials and administration of the heptavalent conjugated pneumococcal polysaccharide vaccine (PCV7) were also associated with reduced prevalence of distinct commensal families (Streptococcaceae and Corynebacteriaceae). In addition, antimicrobial exposure increased the prevalence of Enterobacteriaceae and the abundance of Pasteurellaceae. Other factors, such as age, sex, day care, and a history of recurrent AOM, did ...Continue Reading

References

Nov 1, 1990·International Journal of Pediatric Otorhinolaryngology·J P Dudley, J Sercarz
Aug 1, 1995·Journal of Clinical Microbiology·A SamuelsonA A Lindberg
Sep 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E VaronR Cohen
Mar 2, 2002·The Lancet Infectious Diseases·A SullivanC E Nord
Feb 25, 2003·The Journal of Infectious Diseases·Kathrin MühlemannUNKNOWN Sentinel Working Group
Sep 14, 2004·The Pediatric Infectious Disease Journal·Janet R Casey, Michael E Pichichero
Mar 10, 2005·Vaccine·Allan W CrippsJennelle M Kyd
Apr 16, 2005·Science·Paul B EckburgDavid A Relman
May 26, 2005·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Gary R CooperCornelius J Clancy
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel N FrankNorman R Pace
Mar 15, 2008·Nature Reviews. Microbiology·Aras KadiogluPeter W Andrew
Apr 25, 2008·Journal of Clinical Microbiology·Farah K Bahrani-MougeotPeter B Lockhart
Mar 14, 2009·Vaccine·Anne Vergison
Apr 24, 2009·Journal of Clinical Microbiology·Silvio D BruggerKathrin Mühlemann
May 30, 2009·Science·Elizabeth A GriceJulia A Segre
Jan 7, 2010·PloS One·Markus HiltyWilliam O C Cookson

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Citations

Mar 21, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M JohnS O'Leary
Jan 23, 2013·The Pediatric Infectious Disease Journal·Thijs M A van DongenAnne G M Schilder
Jul 4, 2012·Applied and Environmental Microbiology·Melinda M PettigrewJoshua P Metlay
Nov 14, 2013·Mucosal Immunology·M VissersG Ferwerda
Nov 10, 2014·BMC Bioinformatics·Nils FredrikssonBritt-Marie Wilén
Apr 7, 2016·International Journal of Pharmaceutics·Géraldine BroeckxFilip Kiekens
Jul 8, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Wouter A A de Steenhuijsen PitersDebby Bogaert
Aug 1, 2015·International Journal of Pediatric Otorhinolaryngology·Jake Jervis-BardyRobyn L Marsh
Feb 1, 2015·The Journal of Allergy and Clinical Immunology·Moana MikaMarkus Hilty
May 18, 2016·The Lancet. Respiratory Medicine·Moana MikaUNKNOWN SCILD study group
Nov 2, 2016·Infectious Diseases of Poverty·Regie Lyn P Santos-CortezCharlotte M Chiong
Jul 9, 2016·PLoS Pathogens·Silvio D BruggerKatherine P Lemon
Mar 21, 2017·Nature Reviews. Microbiology·Wing Ho ManDebby Bogaert
Jul 1, 2017·PloS One·Elisabeth S DornBianka S Schulz
Mar 1, 2018·Physiological Reviews·A P HakanssonD Bogaert
Jan 14, 2018·Applied and Environmental Microbiology·Julia G KraemerMarkus Hilty
Jul 1, 2017·American Journal of Respiratory and Critical Care Medicine·Astrid A T M BoschDebby Bogaert
Jan 10, 2018·Frontiers in Microbiology·Nikolai SiemensSven Hammerschmidt
Mar 7, 2014·Journal of Clinical Microbiology·Olga SakwinskaAlain Gervaix
Jul 12, 2018·ERJ Open Research·Moana MikaMarkus Hilty
Oct 10, 2018·The Pediatric Infectious Disease Journal·Wing Ho ManDebby Bogaert
Nov 10, 2017·Journal of Perinatology : Official Journal of the California Perinatal Association·D F KhamashA M Milstone
Aug 11, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S Esposito, N Principi
Apr 12, 2017·The Pediatric Infectious Disease Journal·Matthew S KellyPatrick C Seed
Mar 22, 2020·Applied and Environmental Microbiology·Mirian Domenech, Ernesto García
Jul 5, 2019·Clinical Microbiology Reviews·Marianne F L van den BroekSarah Lebeer
Dec 1, 2015·Pneumonia·Ilan J N KoppenDebby Bogaert
May 15, 2020·Children·Ann-Marie Malby SchoosJakob Stokholm
Jun 8, 2017·Current Allergy and Asthma Reports·Asbjørn Kørvel-HanquistP Homøe
Sep 6, 2020·Journal of Clinical Medicine·Francesco FolinoSara Torretta
Sep 9, 2017·The Journal of General Virology·Stanley LangevinLaurence Josset
Mar 25, 2020·Allergy & Rhinology·Sofia Dimitri-PinheiroPedro Barata

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Datasets Mentioned

BETA
SRA026964.1

Methods Mentioned

BETA
amplicon sequencing
PCR
16S sequencing

Software Mentioned

Mothur
vegan
aov
Pyrotagger
R

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