Nasopharyngeal Pneumococcal Carriage in Nigeria: a two-site, population-based survey

Scientific Reports
Ifedayo M O AdetifaJ Anthony G Scott

Abstract

Changes in nasopharyngeal (NP) carriage of vaccine-type (VT) Streptococcus pneumoniae can be used to assess the effectiveness of a pneumococcal conjugate vaccine (PCV10). We conducted a baseline carriage survey in rural (Kumbotso, Kano) and urban (Pakoto, Ogun) Nigeria. In this cross-sectional study, we obtained data on demography, clinical history, risk factors, and took NP swabs for pneumococcal culture. We calculated crude and age-standardised carriage prevalence and used log-binomial regression to assess risk factors for carriage. Among children aged <5 years, 92% (95% CI: 88-95%) and 78% (73-82%), respectively, carried any pneumococcus and 48% and 50%, respectively, carried PCV10 serotypes. In Kumbotso, carriage prevalence was >40% across all ages. The age-standardized prevalence of pneumococcal carriage was 66% in Kumbotso and 40% in Pakoto. The most commonly identified serotypes were 19 F, 6 A and 23 F. Risk factors for carriage were young age, recent rhinorrhoea, cohabitation with ≥2 children aged <5 years, and sharing a bed with ≥2 persons. Pneumococcal carriage prevalence is high in this Nigerian population. Persisting prevalence of VT-carriage in older children and adults suggests that PCV10 introduction in children ...Continue Reading

References

Jul 27, 1996·Lancet·S K ObaroB M Greenwood
Feb 8, 2005·PLoS Medicine·Benjamin SultanSerge Janicot
Jul 11, 2006·Tropical Medicine & International Health : TM & IH·Richard A AdegbolaTumani Corrah
Aug 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Philip C HillRichard A Adegbola
Feb 24, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A G FaladeR A Adegbola
Jun 16, 2009·Biologicals : Journal of the International Association of Biological Standardization· Who
Sep 15, 2009·Lancet·Katherine L O'BrienUNKNOWN Hib and Pneumococcal Global Burden of Disease Study Team
Jul 24, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sara HaugBruce D Gaynor
Apr 16, 2011·Lancet·Daniel M WeinbergerMarc Lipsitch
May 18, 2011·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Kathleen A EthierPeter R Kerndt
May 21, 2011·BMC Infectious Diseases·Stephen ObaroRichard Adegbola
Aug 24, 2012·Expert Review of Vaccines·Birgit SimellUNKNOWN Pneumococcal Carriage Group
Sep 10, 2013·American Journal of Epidemiology·Daniel M WeinbergerDaniel R Feikin
Jan 28, 2014·PloS One·Effua UsufAndrew Hall
Feb 20, 2014·Journal of Clinical and Diagnostic Research : JCDR·Ravi Kumar K LVandana Ashok
Mar 19, 2014·Environmental Health Perspectives·Carlos Pérez García-PandoMadeleine C Thomson
Apr 1, 2014·Global Health Action·Osman SankohSamuel J Clark
Nov 12, 2014·The New England Journal of Medicine·Anne von GottbergUNKNOWN GERMS-SA Investigators
Mar 29, 2016·The Journal of Infection·Kanny DialloMartin C J Maiden
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pontus NauclerBirgitta Henriques-Normark

❮ Previous
Next ❯

Citations

Jun 12, 2020·The American Journal of Tropical Medicine and Hygiene·Soumeya Hema-OuangraouaJean Bosco Ouedraogo
Sep 2, 2021·The Journal of Infectious Diseases·Louise K Francois WatkinsChris A Van Beneden
Nov 21, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Ellen Signe Filtenborg TvedskovMichaela Tinggaard

❮ Previous
Next ❯

Software Mentioned

Stata

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.