NAT2 fast acetylator genotypes are associated with an increased risk for lung cancer with wildtype epidermal growth factor receptors in Taiwan

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Chun-Nin LeeH Eugene Liu

Abstract

Identifying the risk factors responsible for lung cancer especially for nonsmokers is critical for both its prevention and treatment. Studies have linked the polymorphisms in N-acetyltransferases (NAT2), a key enzyme for metabolism of hydrocarbons, with lung cancer in Asian female nonsmokers. Since a high percentage of lung adenocarcinoma in Asian female nonsmokers contains activating hotspot mutations in epidermal growth factor receptors (EGFR), we hypothesized that NAT2 polymorphisms might represent a risk factor in lung cancer with EGFR mutations. We studied NAT polymorphisms in 117 nonsmall cell lung cancer (NSCLC) patients and in 119 healthy controls and EGFR hotspot mutations in exons 18-21 in 100 of the 117 patients using polymerase chain reactions. NAT2 fast acetylator genotypes were significantly associated with patients with lung cancer (P = 0.04, odds ratio (OR): 1.90, 95% confidence interval (CI): 1.02-3.57). Further analyses revealed that NAT2 fast acetylator genotypes were significantly associated with NSCLC with wildtype EGFR (P = 0.008, OR: 3.16, 95% CI: 1.31-7.63), but not with those with EGFR mutations (P = 0.40). Therefore, NAT2 fast acetylator genotypes are a potential risk factor especially for lung cancer ...Continue Reading

References

Oct 8, 1999·International Journal of Urology : Official Journal of the Japanese Urological Association·H InatomiT Matsumoto
Aug 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·William PaoHarold Varmus
Mar 3, 2005·Journal of the National Cancer Institute·Hisayuki ShigematsuAdi F Gazdar
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Apr 6, 2005·Cancer Letters·Mette SørensenOle Raaschou-Nielsen
Jan 26, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Carmen LillaJenny Chang-Claude
Jan 30, 2007·Carcinogenesis·Federica GemignaniPaul Brennan
Feb 24, 2007·Nature Reviews. Cancer·Sreenath V SharmaDaniel A Haber
May 26, 2007·Diseases of the Colon and Rectum·Chi-Chou HuangHuei Lee
Oct 2, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Young Tae KimJoo Hyun Kim
Mar 20, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·H Eugene LiuHsiang-Yin Chen

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Citations

Feb 5, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Dan CuiWeiquan Lu
Jun 30, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jing-Jing MaXuan Yao
Jun 26, 2013·International Journal of Cancer. Journal International Du Cancer·Jinn-Li WangH Eugene Liu
Jan 20, 2010·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Wan Su, Zhen-ye Xu
Nov 10, 2009·Molecular Biology Reports·Semra DemokanNejat Dalay

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