National antidepressant prescribing in children and adolescents with mental health disorders after an FDA boxed warning

Research in Social & Administrative Pharmacy : RSAP
Manish MittalNancy C Brahm

Abstract

In October 2004, the U.S. Food and Drug Administration (FDA) issued a boxed warning about an increased risk of suicidality (i.e., suicidal ideation, behavior, or attempts) related to all antidepressants in children and adolescents. To describe national antidepressant prescribing patterns in children and adolescents before, during, and after the introduction of the FDA boxed warning. Cross-sectional data from the 2002-2009 National Ambulatory Medical Care Survey (NAMCS) and National Hospital Ambulatory Medical Care Survey (NHAMCS) were used to describe antidepressant prescribing patterns within a nationally-representative sample of 4035 physician visits for children and adolescents diagnosed with depression or other psychiatric disorder(s) [i.e., anxiety disorders or attention deficit/hyperactivity disorder (ADHD)]. In 2002-2003, antidepressants were prescribed in 4.1 million (36.1%) visits, followed by 3.2 million (28.8%) visits in 2004-2005 and 2.8 million (26.8%) visits in 2006-2007. However, antidepressant prescribing patterns reversed during 2008-2009, with an increase to 3.6 million (32.5%) visits. Compared to the period preceding the FDA boxed warning (2002-2003), a significant decline in visits related to antidepressant ...Continue Reading

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Citations

Nov 14, 2017·Journal of Child and Adolescent Psychopharmacology·Nicolas AnsermotChin B Eap
Nov 26, 2016·Social Psychiatry and Psychiatric Epidemiology·Becky MarsDavid Gunnell
Jul 14, 2021·Research in Social & Administrative Pharmacy : RSAP·Rajender R Aparasu, Sanika Rege

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