National Association of Medical Examiners Pediatric Toxicology (PedTox) Registry Report 3. Case submission summary and data for acetaminophen, benzene, carboxyhemoglobin, dextromethorphan, ethanol, phenobarbital, and pseudoephedrine

The American Journal of Forensic Medicine and Pathology
R Hanzlick

Abstract

Data are presented from the National Association of Medical Examiners' (St. Louis, MO, U.S.A.) Pediatric Toxicology (PedTox) Registry. A total of 839 case reports have been submitted to the registry. Reported here are the concentrations of several drugs and potentially toxic substances observed in children who have died of various causes, often non-drug-related. Except for carbon monoxide, for each of the substances addressed in this report, there is insufficient information in the literature to distinguish "lethal" from "non- or sublethal" concentrations in children, and the data are presented only to provide a working frame of reference. For 30 infants whose deaths were attributed to causes other than phenobarbital, the median blood phenobarbital concentration was 7.8 mg/L, with a range of 0.1-22.4 mg/L. For eight infants whose deaths were not attributed to ethanol, the mean blood ethanol concentration was 0.029 gm/dl and ranged from 0.011 gm/dl to 0.050 gm/dl. Blood dextromethorphan concentrations in seven infants showed a mean of 0.38 mg/L and ranged from 0.10 mg/L to 0.95 mg/L. In 15 infants, blood pseudoephedrine concentrations ranged between 0.07 mg/L and 13.0 mg/L, with a mean concentration of 3.55 mg/L. Blood carboxyhe...Continue Reading

Citations

Dec 13, 2006·Archives of Environmental & Occupational Health·Lauren B BallRuth A Etzel
Feb 5, 2014·Archives of Pathology & Laboratory Medicine·Glenn P TaylorM Cristina Pacheco
Sep 13, 2007·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Peter A ChykaUNKNOWN American Assiciation of Poison Control Centers
Dec 23, 2008·Annals of Emergency Medicine·Richard C DartBarry H Rumack
May 8, 2007·Emergency Medicine Clinics of North America·Laura K Bechtel, Christopher P Holstege
Feb 24, 2007·Journal of Forensic Sciences·William E WingertEdward S Chmara
Nov 22, 2008·Toxicology and Industrial Health·S WilburO Faroon

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