National Cancer Database Report of Lymphadenectomy Trends in Endometrial Cancer

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
James CripeGina Mantia-Smaldone

Abstract

Lymph node involvement has a significant impact on prognosis that may direct adjuvant therapy. The role of routine lymph node staging (LNS) is controversial given conflicting results in multiple studies. Our aims are to describe treatment patterns of LNS, identify factors impacting LNS, and quantify the contemporary trends. The National Cancer Data Base was queried for patients undergoing hysterectomy for endometrioid and serous uterine carcinomas from 2003 to 2012. For endometrioid tumors, LNS was considered indicated if at least 1 of 4 criteria was met. Multivariate logistic regression and Cox proportional hazards model were used. A total of 161,683 patients were identified who received hysterectomy for 155,893 (96.4%) endometrioid and 5790 (3.6%) serous carcinomas. Receipt of LNS was significantly associated with greater than 50% myometrial invasion (odds ratio [OR], 1.63; 95% confidence interval [CI], 1.55-1.73), grades 3 to 4 (OR, 3.03; 95% CI, 2.83-3.25), and tumor size greater than 2 cm (OR, 1.17; 95% CI, 1.28-1.26). Of the 97,152 patients with endometrioid carcinoma who met criteria for comprehensive staging, 73,268 (75.4%) underwent LNS. Patients with endometrioid carcinoma meeting criteria for LNS were less likely to ...Continue Reading

References

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Citations

Jan 12, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Chikako MatsushitaMitsuaki Suzuki
Feb 6, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Lilia BougheraraPierre Collinet
Oct 12, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Ming Yin LinKailash Narayan
Nov 2, 2019·International Journal of Cancer. Journal International Du Cancer·Nicole GrauJonathan P Sleeman
Jun 30, 2019·Archives of Gynecology and Obstetrics·Selen BozkurtYasemin Yavuz

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