National Cancer Institute Programmatic Collaboration for Investigational Radiopharmaceuticals

American Society of Clinical Oncology Educational Book
Charles A Kunos, Jacek Capala

Abstract

Radiopharmaceutical therapies have provided an attractive therapeutic approach since the introduction of 131I to treat thyroid cancer. New insights in cancer biology and radiochemistry have brought radiopharmaceuticals to the leading edge of oncology clinical research. National Cancer Institute (NCI) programs watch for new radiopharmaceutical breakthroughs that should be used to treat patients with unmet therapeutic needs. Such efforts occur through leveraged partnerships between NCI's Cancer Therapy Evaluation Program and its Radiation Research Program. If groundbreaking discoveries are made, NCI pulls together clinician scientists to design novel radiopharmaceutical phase I and II monotherapy or combination trials. The specific infrastructure needs, such as radiopharmaceutical dosimetry and treatment planning, demand new programmatic workflow and regulatory oversight. This article discusses a modern approach to the development of radiopharmaceutical therapies in the era of personalized medicine.

References

Jul 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mahesh A VariaUNKNOWN Gynecologic Oncology Group
Dec 4, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert C YoungDavid S Alberts
Oct 23, 2009·Nature·Stephen P Jackson, Jiri Bartek
Jul 2, 2011·Nature·UNKNOWN Cancer Genome Atlas Research Network
Jul 19, 2013·The New England Journal of Medicine·C ParkerUNKNOWN ALSYMPCA Investigators
Nov 23, 2015·Molecular Cell·Mark J O'Connor
Jan 2, 2018·International Journal of Women's Health·Lavanya MariappanYvette Drew

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Citations

Apr 16, 2019·Frontiers in Oncology·Charles A KunosSusan Percy Ivy
Oct 6, 2020·Frontiers in Oncology·Charles A KunosMichael A McDonald
Jul 13, 2019·Frontiers in Oncology·Charles A KunosSusan Percy Ivy

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