National cohort study of opioid analgesic dose and risk of future hospitalization

Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine
Yuanyuan Liang, Barbara J Turner

Abstract

High daily and total doses of opioid analgesics (OAs) increase the risk for drug overdose and may be risks for all-cause hospitalization. To examine the association of OA dose measures with future all-cause hospitalization. Cohort study of 87,688 national health maintenance organization enrollees aged 45 to 64 years with noncancer pain who filled ≥2 OA prescriptions from January 2009 to July 2012. Outcomes were all-cause hospitalization and hospital days in 6-month intervals after the first OA was filled. In generalized linear mixed models, we examined interactions of 5 daily OA dose categories and 5 total dose categories in each 6-month interval adjusted for demographics, clinical conditions, psychotropic drugs, and current hospitalization. For high total OA doses, percentage of days covered by OA prescriptions in 6 months was examined. Over 3 years, an average of 12% of subjects were hospitalized yearly for a mean 6.5 (standard deviation = 8.5) days. Compared with no OAs, adjusted odds of future hospitalization for high total opioid dose (>1830 mg) were 35% to 44% greater depending on daily dose category (all P < 0.05), but total OA dose ≤1830 mg had weak or no association with future hospitalization regardless of daily OA do...Continue Reading

References

Jul 11, 1985·The New England Journal of Medicine·K M Foley
Nov 28, 2007·Archives of Internal Medicine·Vincent S FanUNKNOWN National Emphysema Treatment Trial (NETT) Research Group
Apr 3, 2009·The Journal of Bone and Joint Surgery. American Volume·Cindy L KidnerRobert J Gatchel
Sep 11, 2009·Journal of Managed Care Pharmacy : JMCP·Scott A Strassels
Nov 26, 2009·Psychological Reports·Leon A HyerJoe Sam Robinson
Jan 15, 2010·Pain Practice : the Official Journal of World Institute of Pain·K C P VissersB Morlion
Jan 20, 2010·Annals of Internal Medicine·Kate M DunnMichael Von Korff
Jun 29, 2010·Journal of Pain and Symptom Management·Mark J EdlundMark D Sullivan
Dec 15, 2010·Archives of Internal Medicine·Daniel H SolomonSebastian Schneeweiss
Apr 7, 2011·JAMA : the Journal of the American Medical Association·Amy S B BohnertFrederic C Blow
Oct 27, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Leonard J PaulozziLarry D Loring
Nov 8, 2011·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Andrea FurlanAngela Mailis-Gagnon
Feb 9, 2012·Population Health Management·Tobias FreundFrank Peters-Klimm
Jan 3, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Alex CahanaDennis C Turk
Nov 13, 2013·Annals of Internal Medicine·Teryl K NuckolsRoger Chou
Dec 7, 2013·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Hilary J MosherMark W Vander Weg
Feb 21, 2014·BMJ : British Medical Journal·Anupam B JenaPinar Karaca-Mandic
Jul 6, 2014·Clinical Transplantation·Satyarth KulshresthaFu L Luan

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Citations

Nov 26, 2015·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Pranathi R SundaragiriNeel B Shah
Jul 17, 2015·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Santosh GautamBarbara J Turner
Dec 1, 2015·The Journal of Pain : Official Journal of the American Pain Society·Santosh GautamBarbara J Turner
Apr 29, 2015·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Shoshana J Herzig
Nov 25, 2016·Journal of Managed Care & Specialty Pharmacy·Catherine I StarnerPatrick P Gleason
Aug 8, 2019·Current Pain and Headache Reports·Luisa M BigalStephanie Dunbar
Dec 28, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Yuanyuan LiangBarbara J Turner
Jul 25, 2019·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Marisha BurdenRichard K Albert
Jul 23, 2018·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Michele BuonoraJoanna L Starrels
Jun 20, 2020·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Mikhail ZusmanovichThomas Youm

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