National Costs Associated With Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus Hospitalizations in the United States, 2010-2014

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Eili Y KleinTrish M Perl

Abstract

Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) have been associated with worse patient outcomes and higher costs of care than methicillin-susceptible (MSSA) infections. However, since prior studies found these differences, the healthcare landscape has changed, including widespread dissemination of community-associated strains of MRSA. We sought to provide updated estimates of the excess costs of MRSA infections. We conducted a retrospective analysis using data from the National Inpatient Sample from the Agency for Healthcare Research and Quality for the years 2010-2014. We calculated costs for hospitalizations, including MRSA- and MSSA-related septicemia and pneumonia infections, as well as MRSA- and MSSA-related infections from conditions classified elsewhere and of an unspecified site ("other infections"). Differences in the costs of hospitalization were estimated using propensity score-adjusted mortality outcomes for 2010-2014. In 2014, estimated costs were highest for pneumonia and sepsis-related hospitalizations. Propensity score-adjusted costs were significantly higher for MSSA-related pneumonia ($40725 vs $38561; P = .045) and other hospitalizations ($15578 vs $14792; P < .001) than for MRSA-rela...Continue Reading

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Citations

Aug 29, 2019·Journal of Breath Research·Carrie L Jenkins, Heather D Bean
Jul 31, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nicole M WhiteNicholas Graves
Jul 21, 2020·American Journal of Medical Quality : the Official Journal of the American College of Medical Quality·Alessandra B Garcia ReevesMorris Weinberger
Dec 30, 2020·Chemical Reviews·Jed F Fisher, Shahriar Mobashery
May 15, 2021·American Journal of Infection Control·Kengo InagakiCharlotte V Hobbs
Nov 2, 2019·ACS Chemical Biology·Navid J Ayon, William G Gutheil
Dec 4, 2020·ACS Infectious Diseases·Emma R GuibersonJeffrey M Spraggins

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