National food-fortification program with folic acid in Chile

Food and Nutrition Bulletin
Eva Hertrampf, Fanny Cortes

Abstract

The Chilean Ministry of Health legislated to add folic acid (2.2 mg/100 g) to wheat flour to reduce the risk of neural tube defects (NTD), beginning in January 2000. This policy resulted in a significant increase in serum and red blood cell folate in women of childbearing age 1 year after fortification. The frequency of NTD was studied in all births, both live and stillbirths, in a prospective hospital-based design including 25% of national births during 1999-2000 (prefortification period) and 2001-2002 (postfortification period). During the prefortification period, there was a total of 120,566 newborns, and the NTD rate was 17.1/10,000 births. During the postfortification period (2001-2002) there was a total of 117,704 newborns, and the NTD rate was significantly reduced by 43% to 9.7/10,000 births (RR = 0.57; 95% CI, 0.45 to 0.71). This implies a reduction of 43% in the rate of NTD. The costs per NTD case and infant death averted were 1,200 international dollars (I$) and I$11,000, respectively. The cost per disability-adjusted life year (DALY) averted was I$91, or 0.8% of the country's per capita GDP. On the overall, fortification resulted in net cost savings of I$1.8 million. Fortification of wheat flour with folic acid has ...Continue Reading

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Citations

May 20, 2011·European Journal of Pediatrics·Yunni YiClaire Snowball
Apr 21, 2017·Congenital Anomalies·Atsuo KondoHiromi Fukuda
Aug 20, 2008·Food and Nutrition Bulletin·José F CorderoR J Berry
Oct 7, 2011·Australian and New Zealand Journal of Public Health·Jessica K EmmettMalcolm Riley
Oct 1, 2013·Birth Defects Research. Part A, Clinical and Molecular Teratology·Atsuo KondoTomoyuki Watanabe
May 12, 2017·Food and Nutrition Bulletin·Reynaldo Martorell, Daniel López de Romaña
Jan 23, 2020·International Journal of Environmental Research and Public Health·Martina BarchittaAntonella Agodi
Apr 8, 2009·Therapeutic Drug Monitoring·Carolyn TamGideon Koren
Jun 20, 2012·American Journal of Medical Genetics. Part a·Fanny CortésE Hertrampf
Oct 5, 2015·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Mark A HansonJessica L Morris
Jul 1, 2014·Journal of Global Health·Annie LoSimrita Sidhu
Dec 12, 2012·The Journal of Nutrition·Viktoria RabovskajaStephen Goodall
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Mar 25, 2016·Birth Defects Research. Part A, Clinical and Molecular Teratology·Jorge RosenthalEunice Lopez-Pazos
May 11, 2011·Deutsches Ärzteblatt International·Wolfgang Herrmann, Rima Obeid

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