National Institute for Health Research Health Informatics Collaborative (NIHR HIC): Development of a Pipeline to Collate Electronic Clinical Data for Viral Hepatitis Research

MedRxiv : the Preprint Server for Health Sciences
D. A. SmithEleanor Barnes

Abstract

Objective: The National Institute of Health Research (NIHR) Health Informatics Collaborative (HIC) is a programme of infrastructure development across NIHR Biomedical Research Centres (BRCs). The aim of the NIHR HIC is to improve the quality and availability of routinely-collected data for collaborative, cross-centre research. This is demonstrated through research collaborations in selected therapeutic areas, one of which is viral hepatitis. Design: The collaboration in viral hepatitis identified a rich set of data points, including information on clinical assessment, antiviral treatment, laboratory test results, and health outcomes. Clinical data from different centres was standardised and combined to produce a research-ready dataset; this was used to generate insights regarding disease prevalence and treatment response. Results: A comprehensive database has been developed for potential viral hepatitis research interests, with a corresponding data dictionary for researchers across the centres. An initial cohort of 960 patients with chronic hepatitis B infections and 950 patients with chronic hepatitis C infections has been collected. Conclusion: For the first time, large prospective cohorts are being formed within NHS secondar...Continue Reading

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