National prospective surveillance study of necrotizing enterocolitis in neonatal intensive care units

Journal of Pediatric Surgery
Clare M ReesAgostino Pierro

Abstract

There is scant epidemiological data on necrotizing enterocolitis (NEC), so we conducted a national study to characterize prevalence, surgical management, and mortality. A prospective cross-sectional survey was performed in the United Kingdom requesting data from 158 level 2 and 3 neonatal intensive care units (NICUs) during 2 winter and 2 summer months in 2005 to 2006; 51% of questionnaires were returned. Results are given as percentage with 95% confidence intervals. (1) Period prevalence: 211 infants were diagnosed with NEC (45% Bell's stage I, 21% stage II, and 33% stage III) from a total of 10,946 NICU admissions, with a period prevalence of 2% (1.7-2.2). In infants less than 1000 g birth weight, the prevalence was 14% (12-16), and in less than 26 weeks of gestation, 14% (11-17). Prevalence decreased significantly with increasing birth weight (P < .0001) and increasing gestation (P < .0001). (2) SURGERY: 66 infants received surgical procedures; peritoneal drain in 13 (followed by laparotomy in 8) and in 53, laparotomy alone. (3) Mortality: 27 infants died with NEC of a total 283 deaths, thus, accounting for 9.5% of NICU mortality. Eight (30%) infants with NEC died without surgery. Prevalence of NEC in the United Kingdom is h...Continue Reading

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Citations

Jul 9, 2011·The British Journal of Nutrition·Simon Eaton
May 24, 2014·Journal of Pediatric Surgery·Sherif El-KadyRobert Baird
Dec 10, 2013·Journal of Pediatric Surgery·Nigel J HallAgostino Pierro
Dec 6, 2014·Archives of Disease in Childhood·S PokhrelM J Renfrew
Dec 23, 2011·American Journal of Obstetrics and Gynecology·Marie-Josée RaboissonJean-Claude Fouron
Sep 3, 2016·Journal of Neonatal-perinatal Medicine·M J MϋllerS Seeliger
Jan 28, 2017·Scientific Reports·Benjamin AllinUNKNOWN British Association of Paediatric Surgeons Congenital Anomalies Surveillance System Necrotising Enterocolitis Collaboration
Apr 6, 2018·Journal of Pediatric Gastroenterology and Nutrition·Kristen H ShanahanCamilia R Martin
Aug 8, 2018·Emerging Microbes & Infections·Raymond Kiu, Lindsay J Hall
Feb 27, 2016·F1000Research·Augusto Zani, Agostino Pierro
Oct 28, 2015·Journal of Pediatric Gastroenterology and Nutrition·William Diehl-JonesJames K Friel
Apr 25, 2018·Mediators of Inflammation·Chariton MoschopoulosVineet Bhandari
Feb 7, 2021·Pediatric Surgery International·Edoardo BindiAgostino Pierro
Apr 26, 2021·European Journal of Pediatrics·Walusa Assad Gonçalves-FerriLourenço Sbragia Neto
Apr 2, 2021·Case Reports in Gastroenterology·Thanh Xuan NguyenHoai Anh Vu

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