Abstract
The natural history of renal allograft in recipients who have sickle cell disease or trait has not been widely studied. This survey attempted to collect all the case histories known at present and to assess the relationship of sickle cell disease or trait to the natural history of renal allograft. A questionnaire was sent to 120 transplant centers in North America. 106 centers responded to the study, compliance rate being 88%. 88 centers reported not having any experience with such a case, whereas 18 centers transplanted 34 kidneys in 30 patients with this disease or trait. 9 of these had sickle cell disease and 21 had the trait. Graft survival at 1 year was 23 of 34, i.e., 67%. Mortality was 4 of 30, i.e., 13% in the first year. Sickle cell crisis was noted in 8 patients during the first year, 7 of whom had sickle cell disease. Thus, sickle cell crisis is very common in sickle cell transplant patients. From the points of view of patient survival and graft survival, recipients of kidneys who have the disease or the trait do just as well after transplant as the remaining patient population.
Citations
Jun 6, 2000·The Journal of Pediatrics·D R WigfallJ W Foreman
Jun 18, 2002·Clinical and Laboratory Haematology·B Myers, S M Donohue
Jan 5, 2000·Kidney International·P T PhamS Q Lew
Apr 2, 1992·The New England Journal of Medicine·R J FalkJ C Jennette
Feb 12, 1999·Transplantation·A O OjoL Y Agodoa
Mar 9, 2000·Transplantation·S EmreC M Miller
Oct 1, 1992·Postgraduate Medical Journal·C R Tomson
Feb 9, 2012·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Jay NathNicholas G Inston
Jun 17, 2009·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Gustavo Brandão Fischer, Ana Cecília Michel da Rosa
Jul 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E L Ramos, C C Tisher
Oct 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D J MinerJ E Tomaszewski
May 1, 1985·Kidney International·P E de Jong, L W Statius van Eps
Oct 16, 2008·Kidney International·Edward J O'RourkeMark Harber
Feb 5, 2011·Human Pathology·Lisa KimShane M Meehan
Sep 10, 2011·British Journal of Haematology·Claire C Sharpe, Swee L Thein
Jan 1, 1989·Annals of the New York Academy of Sciences·H A Pearson
May 22, 2013·Journal of Transplantation·U H Okafor, E Aneke
Mar 11, 2015·British Journal of Haematology·Nigel S KeyVimal K Derebail
Jan 1, 2012·Case Reports in Nephrology·U H OkaforF S Wokoma
Jul 10, 2014·Pulmonary Circulation·M Patricia GeorgeMark T Gladwin
Mar 15, 2018·Blood Advances·Hitomi HosoyaSaar Gill
Feb 4, 2003·Seminars in Nephrology·Jon I Scheinman
Jan 16, 1999·Journal of the American Society of Nephrology : JASN·P Saborio, J I Scheinman