National survey data for zoonotic schistosomiasis in the Philippines grossly underestimates the true burden of disease within endemic zones: implications for future control

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Remigio M OlvedaAllen G P Ross

Abstract

Zoonotic schistosomiasis has a long endemic history in the Philippines. Human mass drug administration has been the cornerstone of schistosomiasis control in the country for the past three decades. Recent publications utilizing retrospective national survey data have indicated that the national human prevalence of the disease is <1%, hence the disease is now close to elimination. However, the evidence for such a claim is weak, given that less than a third of the human population is currently being treated annually within endemic zones and only a third of those treated actually swallow the tablets. For those who consume the drug at the single oral dose of 40mg/kg, the estimated cure rate is 52% based on a recent meta-analysis. Thus, approximately 5% of the endemic human population is in reality receiving the appropriate treatment. To compound this public health problem, most of the bovines in the endemic communities are concurrently infected but are not treated under the current national control programme. Given this evidence, it is believed that the human prevalence of schistosomiasis within endemic regions has been grossly underestimated. Inherent flaws in the reporting of national schistosomiasis prevalence data are reported ...Continue Reading

References

Apr 15, 2004·Parasitology International·Bayani L BlasMasataka Hayashi
Mar 30, 2010·The American Journal of Tropical Medicine and Hygiene·Hai-Wei WuJonathan D Kurtis
Apr 16, 2013·Acta Tropica·Lydia LeonardoRaman Velayudhan
Aug 12, 2014·Clinical Microbiology : Open Access·David U OlvedaAllen G P Ross
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Citations

Oct 27, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·David U OlvedaAllen G P Ross
Nov 7, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·David U OlvedaAllen G Ross
Oct 27, 2016·Current Opinion in Infectious Diseases·David U OlvedaAllen G P Ross
Sep 5, 2020·Clinical Case Reports·Eman AbdelghaniCarmen P Escalante
Apr 25, 2019·Tropical Medicine and Infectious Disease·Remigio M Olveda, Darren J Gray
Aug 15, 2018·Parasites & Vectors·Andrea L Araujo NavasAlfred Stein

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International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
David U OlvedaAllen G P Ross
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