National Trends in Colorectal Cancer Incidence Among Older and Younger Adults in Canada

JAMA Network Open
Darren R BrennerRobert J Hilsden

Abstract

Recent evidence has shown that although the incidence of colorectal cancer (CRC) is decreasing among older adults, rates have increased in adults younger than 50 years. Given that younger adults are typically classified as at low risk for the disease, this epidemiologic shift is cause for concern. To analyze Canadian national cancer incidence registries to determine incidence trends for CRC among older and younger adults, updated to 2015. This cohort study determined the incidence of CRC using data from the National Cancer Incidence Reporting System (1969-1992) and the Canadian Cancer Registry (1992-2015). All Canadians diagnosed with CRC from January 1, 1969, through December 31, 2015, were included in this study. Trends among men and women were examined separately and by age category (>50 vs <50 years). Birth cohort models were fit using 5-year groups starting in 1886, with 1936 as the reference cohort. Data were analyzed from May 13, 2018 to May 16, 2018. Annualized percentage changes and incidence rate ratios of CRC. From 1971 to 2015, 688 515 incident cases (52.9% women) of CRC were identified. Although the incidence of CRC has decreased in older men and women, rates among younger men and women have increased since 2006 an...Continue Reading

References

Nov 3, 2010·Clinics in Colon and Rectal Surgery·Fatima A Haggar, Robin P Boushey
Aug 26, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Philip S RosenbergWilliam F Anderson
Mar 2, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Apr 5, 2017·Journal of the National Cancer Institute·Rebecca L SiegelAhmedin Jemal
Oct 11, 2017·Preventive Medicine·Darren R BrennerRobert J Hilsden
Feb 2, 2018·Journal of Clinical Medicine·Benjamin E AnsaSelina A Smith
May 31, 2018·CA: a Cancer Journal for Clinicians·Andrew M D WolfRobert A Smith
Aug 17, 2018·Current Oncology·C A KimUNKNOWN Western Canadian Gastrointestinal Cancer Group
Aug 31, 2018·Gastroenterology·Caitlin C MurphyRobert S Sandler
Sep 8, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jie-Bin LewKaren Canfell

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Citations

Aug 10, 2020·Cancer·Emily V HeerMiranda M Fidler-Benaoudia
Jan 3, 2021·Cellular Signalling·Neda YaghoubiSeyed Hamid Aghaee-Bakhtiari
Jan 26, 2021·Journal of the National Cancer Institute·Stacey A FedewaRebecca L Siegel
Feb 25, 2021·Cancer Medicine·Katharina M ScheurlenSusan Galandiuk
May 28, 2020·Minerva chirurgica·Paolo Del RioPaolo Dell'abate
Sep 17, 2021·BMJ : British Medical Journal·Priyanka Kanth, John M Inadomi
Sep 17, 2021·Neurology·Ruth Ann MarriePatti Groome
Dec 6, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ghislaine SceloLorenzo Richiardi

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