Nationwide bowel cancer screening programme in England: cohort study of lifestyle factors affecting participation and outcomes in women

British Journal of Cancer
R G BlanksJ Green

Abstract

In 2006, the National Health Service Bowel Cancer Screening Programme in England (NHSBCSP) began offering routine population-based biennial faecal occult blood testing (FOBt) at ages 60-69. There is, however, limited information on how characteristics of individuals affect participation and outcomes of screening, and we studied this association by linking NHSBCSP data to a large prospective cohort of women. Electronic linkage of the NHSBCSP and Million Women Study records identified 899 166 women in the study cohort with at least one invitation for screening. NHSBCSP provided information on screening acceptance, FOBt results, screen-detected colorectal cancer and other outcomes. The Million Women Study provided prospectively collected information on personal and lifestyle factors. Multiple regression was used to estimate relative risks (RRs) of factors associated with acceptance and outcomes of screening. Overall, 70% of women (628 976/899 166) accepted their first invitation for bowel cancer screening, of whom 9133 (1.5%) were FOBt-positive, 743 (0.1%) had screen-detected colorectal cancer and 3056 (0.5%) had screen-detected colorectal adenoma. Acceptance was lower in women from the most than the least deprived tertile, in Sou...Continue Reading

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Citations

Nov 9, 2016·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Lindsay C KobayashiJane Wardle
Feb 13, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J SongJ He
Jan 31, 2018·British Journal of Cancer·J A Usher-SmithS J Griffin
Jul 7, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Verna LavenderSusie Pearce
May 28, 2019·Journal of Epidemiology and Community Health·Lucy GavensAndrew Muirhead
Jan 3, 2020·International Journal of Cancer. Journal International Du Cancer·Andreas BjerrumElsebeth Lynge
Jun 13, 2019·European Journal of Epidemiology·TienYu Owen YangUNKNOWN Million Women Study Collaborators
Jan 12, 2017·Gut·C M de KlerkUNKNOWN Expert Working Group ‘Coalition to reduce inequities in colorectal cancer screening’ of the World Endoscopy Organization
Aug 31, 2018·Nature Reviews. Gastroenterology & Hepatology·Martin C S WongSiew C Ng
Jul 31, 2019·JNCI Cancer Spectrum·Claire M VajdicMaarit A Laaksonen
Nov 20, 2016·International Journal of Cancer. Journal International Du Cancer·Andrea Burón PustUNKNOWN Million Women Study Collaborators
Nov 26, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Rashmi SinhaNicholas Chia

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