Nationwide epidemic of septicemia caused by contaminated intravenous products: mechanisms of intrinsic contamination.

Journal of Clinical Microbiology
D C MackelJ V Bennett

Abstract

Between 1 July 1970 and April 1971, in many hospitals in this country, there were outbreaks of nosocomial septicemia caused by Enterobacter cloacae of E. agglomerans (formerly Erwinia, herbicola-lathyri). All of these hospitals used infusion products manufactured by one company, Abbott Laboratories, and all affected patients had onset of septicemia while receiving the company's infusion products. Septicemia was epidemiologically and microbiologically traced to intrinsic contamination of the company's screw-cap closure for infusion bottles which was sealed with a newly introduced elastomer liner. Epidemic organisms were isolated from these closures. Investigations both in the laboratory and in the manufacturing plant into the mechanism of contamination of these products revealed the following. (i) Epidemic strains were present in numerous areas throughout the manufacturing plants. (ii) Viable microorganisms gained access to the interior of screw-cap closures after the autoclave step of production. (iii) Cooling closures actively drew moisture through the thread interstices into the inner-most depths of the closure. (iv) Transfer of contaminants from closures to fluid was easily effected by simple manipulations duplicating normal...Continue Reading

References

Feb 4, 1971·The New England Journal of Medicine·R J DumaH P Dalton
Jun 1, 1970·American Journal of Obstetrics and Gynecology·R A Sack
May 1, 1968·Archives of Environmental Health·H G BourneS Seferian
Jul 4, 1964·The Medical Journal of Australia·J M GARVAN, B W GUNNER

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Citations

Jul 7, 2005·The Pediatric Infectious Disease Journal·Kelly L MooreFrank Mahoney
Jan 1, 1981·Critical Reviews in Microbiology·R F D'AmatoE J Bottone
May 1, 1996·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·A E Macías-HernándezS Ponce-de-León-Rosales

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