Nationwide oral poliovirus vaccination campaign and the incidence of Guillain-Barré Syndrome

American Journal of Epidemiology
E KinnunenT Hovi

Abstract

A retrospective analysis of the incidence of Guillain-Barré syndrome (GBS) in Finland in 1981-1986 was carried out by careful examination of medical records identified from nationwide Hospital Discharge Register data based on a mean total population of 5 million people. Records from 247 patients fulfilled the accepted criteria of GBS corresponding to a mean annual incidence of 0.82 per 100,000 population. Monthly rates showed an increased incidence of GBS in March 1985, following by a few weeks the onset of the nationwide oral poliovirus vaccine campaign and partly overlapping it. Analysis of the time series in depth suggested, however, that a change point in the occurrence of GBS had already taken place before the oral poliovirus vaccine campaign. Widespread circulation of wild-type 3 poliovirus in the population immediately preceded the oral poliovirus vaccine campaign and the peak occurrence of GBS. These results demonstrate a temporal association between poliovirus infection, caused by either wild virus or live attenuated vaccine, and an episode of increased occurrence of GBS, but they cannot prove the suspected cause-effect relation between GBS and oral poliovirus vaccine administration.

Citations

Oct 5, 2010·Clinical Reviews in Allergy & Immunology·Eitan IsraeliYehuda Shoenfeld
Sep 24, 1998·Lancet·A F Hahn
Mar 1, 2000·Journal of Neuroimmunology·R A HughesK J Smith
May 16, 2000·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Q ChengJ De Pedro-Cuesta
Aug 18, 2000·Paediatric Drugs·R T ChenF DeStefano
Jun 19, 2004·Journal of Drug Targeting·Alan W BairdDavid J Brayden
Dec 17, 2015·Journal of Neurovirology·Salman NaeemAmmad Fahim
Jul 20, 2002·Arquivos de neuro-psiquiatria·Elza Dias-Tosta, Carlos Santos Kückelhaus
Apr 25, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Penina HaberFrank DeStefano
Dec 31, 2003·Journal of Child Neurology·Marco R MolineroFrancisco Cleaves
Nov 3, 2017·Journal of the Peripheral Nervous System : JPNS·Jussi O T SipiläVille Kytö
Feb 14, 2007·Acta Neurologica Scandinavica·S MarkoulaG Lagos
Jun 5, 2010·International Reviews of Immunology·Simonetta Salemi, Raffaele D'Amelio
Dec 16, 1998·Current Opinion in Neurology·H P HartungJ D Pollard
May 14, 2005·The British Journal of Surgery·M R StephensM C Allison
Jul 19, 2012·Pharmacoepidemiology and Drug Safety·Priscilla VelentgasRichard Platt
Sep 20, 2001·Current Opinion in Neurology·V Govoni, E Granieri

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