PMID: 11923553Mar 30, 2002Paper

Nationwide prevalence of sporadic and familial idiopathic pulmonary fibrosis: evidence of founder effect among multiplex families in Finland

Thorax
U HodgsonP Tukiainen

Abstract

The prevalence of sporadic and familial idiopathic pulmonary fibrosis (IPF) cases in Finland was evaluated according to the revised recommendations of the American Thoracic Society. All Finnish pulmonary clinics (n=29) were included in the primary screening. Hospital data bases were used to identify patients with the diagnosis "alveolitis fibroticans idiopathica" (J84.1 in ICD-10 classification). The total number of patients with IPF was extrapolated based on the evaluation of random samples of case records in different centres. Families with more than one potentially affected member were identified from a questionnaire study and the diagnosis was verified from the medical records. Using this approach, the nationwide prevalence of IPF in Finland was estimated to be 16-18/100 000. In 90% of the patients lung involvement was assessed by high resolution computed tomographic (HRCT) scanning and in 31% a surgical biopsy specimen was available, further confirming the diagnosis. Seventeen multiplex families with 2-5 affected family members were identified, giving a prevalence of 5.9/million for familial IPF in Finland. Both multiplex and sporadic families were clustered in Eastern Finland. This clustering reflects the demographic hist...Continue Reading

References

May 22, 1986·The New England Journal of Medicine·P B BittermanR G Crystal
Jan 1, 1994·Acta Universitatis Palackianae Olomucensis Facultatis Medicae·V Kolek
Oct 1, 1994·American Journal of Respiratory and Critical Care Medicine·D B CoultasR E Sobonya
Sep 1, 1994·American Journal of Respiratory and Critical Care Medicine·K IwaiY Hosoda
Jan 1, 1997·The International Journal of Biochemistry & Cell Biology·R P MarshallG J Laurent
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·A F VuorioK Kontula
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·A L Katzenstein, J L Myers
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·A de la Chapelle, F A Wright
Sep 2, 1999·Human Molecular Genetics·L PeltonenT Varilo
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·M WhyteF Di Giovine
Oct 6, 2000·The Journal of Clinical Investigation·H HuopioT Otonkoski
Mar 17, 2001·Nature Reviews. Genetics·L PeltonenK Lange
Oct 1, 1950·Diseases of the Chest·J W PEABODYE W HAYES

❮ Previous
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Citations

Sep 15, 2010·Clinical Reviews in Allergy & Immunology·Andrea T BorchersM Eric Gershwin
Mar 23, 2005·The Journal of Experimental Medicine·Amir AbdollahiPeter E Huber
Oct 5, 2007·Nucleic Acids Research·Christine Kim GarciaJerry W Shay
Jul 3, 2004·Journal of Computer Assisted Tomography·Osamu NishiyamaNestor L Müller
Aug 24, 2006·Current Opinion in Pulmonary Medicine·J Shirine Allam, Andrew H Limper
Jan 21, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yasuhiro SetoguchiYoshinosuke Fukuchi
Jul 29, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Shoji OhnoYukihiko Sugiyama
Jan 31, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Harikrishna TanjoreWilliam E Lawson
Mar 27, 2012·Pulmonary Medicine·Chad K OhNestor A Molfino
Nov 27, 2007·Respiration; International Review of Thoracic Diseases·Mark P Steele, Kevin K Brown
Aug 20, 2005·American Journal of Respiratory and Critical Care Medicine·Mark P SteeleDavid A Schwartz
Jul 1, 2006·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuGerry Oster
Jul 21, 2007·American Journal of Respiratory and Critical Care Medicine·Ivan O RosasBernadette R Gochuico
Jun 23, 2009·American Journal of Respiratory and Critical Care Medicine·David J LedererR Graham Barr
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
Jul 27, 2010·American Journal of Respiratory and Critical Care Medicine·Coline H M van MoorselJan C Grutters
Dec 3, 2010·American Journal of Respiratory and Critical Care Medicine·William E Lawson, James E Loyd
Mar 1, 2012·American Journal of Respiratory and Critical Care Medicine·Tracy J DoyleIvan O Rosas
Mar 26, 2013·American Journal of Respiratory Cell and Molecular Biology·Bethany B MooreCory M Hogaboam
Aug 22, 2013·BMC Pulmonary Medicine·Jaana KaunistoMarjukka Myllärniemi
Oct 19, 2012·Orphanet Journal of Rare Diseases·Paolo SpagnoloLuca Richeldi
Nov 14, 2012·Multidisciplinary Respiratory Medicine·Paolo SpagnoloLuca Richeldi
Dec 27, 2012·Disease Models & Mechanisms·Jonathan A KropskiTimothy S Blackwell
Jun 2, 2006·Proceedings of the American Thoracic Society·William E Lawson, James E Loyd
Apr 12, 2008·Proceedings of the American Thoracic Society·David A Schwartz
Oct 31, 2012·Archives of Pathology & Laboratory Medicine·Kevin O LeslieDavid A Schwartz
Sep 17, 2013·American Journal of Respiratory and Critical Care Medicine·William D TravisUNKNOWN ATS/ERS Committee on Idiopathic Interstitial Pneumonias
Jul 18, 2012·Proceedings of the American Thoracic Society·Ken Macneal, David A Schwartz
Jun 4, 2011·Pulmonary Medicine·Riitta Kaarteenaho, Vuokko L Kinnula
Dec 17, 2014·Clinical Pulmonary Medicine·Janet L TalbertMark P Steele
May 31, 2014·The Lancet. Respiratory Medicine·Marjukka Myllärniemi
Jul 7, 2007·Chronobiology International·Timo HannuTapio Vehmas
Jan 25, 2011·Annals of Medicine·Ville PulkkinenMarjukka Myllärniemi
May 27, 2011·The American Journal of the Medical Sciences·William E LawsonAmber L Degryse
Nov 26, 2013·Radiologic Clinics of North America·Stephen Hobbs, David Lynch
Oct 23, 2010·Chest·Souheil El-ChemalyBernadette R Gochuico
Oct 30, 2012·Immunology and Allergy Clinics of North America·Jason S Zolak, Joao A de Andrade
Jan 26, 2005·Mayo Clinic Proceedings·Hassan F NadrousJay H Ryu
Jul 2, 2011·Lancet·Talmadge E KingMoisés Selman
May 12, 2010·International Journal of Radiation Oncology, Biology, Physics·Paul FlechsigPeter E Huber
Dec 8, 2009·La Presse médicale·Dominique ValeyreHilario Nunes

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