Native glycine receptor subtypes and their physiological roles

Neuropharmacology
Joseph W Lynch

Abstract

The glycine receptor chloride channel (GlyR), a member of the pentameric Cys-loop ion channel receptor family, mediates inhibitory neurotransmission in the spinal cord, brainstem and retina. They are also found presynaptically, where they modulate neurotransmitter release. Functional GlyRs are formed from a total of five subunits (alpha1-alpha4, beta). Although alpha subunits efficiently form homomeric GlyRs in recombinant expression systems, homomeric alpha1, alpha3 and alpha4 GlyRs are weakly expressed in adult neurons. In contrast, alpha2 homomeric GlyRs are abundantly expressed in embryonic neurons, although their numbers decline sharply by adulthood. Numerous lines of biochemical, biophysical, pharmacological and genetic evidence suggest the majority of glycinergic neurotransmission in adults is mediated by heteromeric alpha1beta GlyRs. Immunocytochemical co-localisation experiments suggest the presence of alpha2beta, alpha3beta and alpha4beta GlyRs at synapses in the adult mouse retina. Immunocytochemical and electrophysiological evidence also implicates alpha3beta GlyRs as important mediators of glycinergic inhibitory neurotransmission in nociceptive sensory neuronal circuits in peripheral laminae of the spinal cord dors...Continue Reading

References

Jul 1, 1978·The Journal of Physiology·J L Barker, B R Ransom
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D LangoschH Betz
May 13, 1967·Nature·R A DavidoffR Werman
May 13, 1967·Nature·R WermanM H Aprison
Sep 30, 1967·Nature·D R CurtisG A Johnston
Nov 1, 1965·Life Sciences·M H Aprison, R Werman
Dec 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·S F KingsmoreM F Seldin
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·N RundströmD Langosch
Nov 14, 1997·Brain Research. Developmental Brain Research·M Kungel, E Friauf
Nov 18, 1998·Journal of Neurophysiology·J H SingerA J Berger
Sep 2, 1999·The EMBO Journal·N GriffonH Betz
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·P J CorringerJ P Changeux
Sep 22, 2000·Molecular Pharmacology·S Supplisson, D Chesnoy-Marchais
Feb 17, 2001·Molecular and Cellular Neurosciences·K D PierceP R Schofield
Mar 30, 2001·The Journal of Biological Chemistry·Q ShanJ W Lynch
Jul 5, 2001·Cellular and Molecular Life Sciences : CMLS·P Legendre
Aug 28, 2001·Neuropharmacology·G MaksayH Betz
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Rostislav Turecek, Laurence O Trussell
Apr 8, 2003·The Journal of Physiology·Trevor M LewisAnnette M L McClellan
Jun 27, 2003·Nature·Atsuo MiyazawaNigel Unwin

❮ Previous
Next ❯

Citations

Oct 24, 2012·JAMA Neurology·Andrew McKeonJosep Dalmau
Aug 19, 2011·Histochemistry and Cell Biology·Stefanie BuerbankJulia Dlugaiczyk
Sep 17, 2013·Cell Biology and Toxicology·Timothy C Marrs, R L Maynard
Dec 28, 2011·Documenta Ophthalmologica. Advances in Ophthalmology·Charlene B Y KimT Michael Nork
Sep 21, 2010·Quarterly Reviews of Biophysics·Andrew J ThompsonSarah C R Lummis
Jan 22, 2013·ACS Chemical Neuroscience·Stefanie C AltieriAnne M Andrews
Jan 15, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kimberly A BadanichJohn J Woodward
Sep 22, 2012·The Journal of Biological Chemistry·Bea UntererCarmen Villmann
Sep 14, 2013·The Journal of Biological Chemistry·Jane E CarlandJeremy J Lambert
Nov 1, 2011·The Journal of Pharmacology and Experimental Therapeutics·Cecilia M BorgheseR Adron Harris
Oct 16, 2009·Annual Review of Physiology·Charity DuranH Criss Hartzell
Nov 29, 2012·The Journal of Clinical Investigation·Irene LeckerBeverley A Orser
Sep 9, 2011·PloS One·Gonzalo E Yévenes, Hanns Ulrich Zeilhofer
Nov 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bohdana HruskovaRostislav Turecek
Sep 14, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nela DurisicJoseph A Dent
Mar 19, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qing Chang, Lee J Martin
Jan 25, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ruili Xie, Paul B Manis
Apr 13, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wei XiongLi Zhang
Mar 24, 2011·Future Medicinal Chemistry·Elena ColomboPaolo Pevarello
Jan 17, 2014·Natural Product Reports·Ryuichi Sakai, Geoffrey T Swanson
Jan 1, 2014·Neuroscience Letters·Julia V BukanovaVladimir G Skrebitsky
Sep 14, 2013·Brain : a Journal of Neurology·Rhys H ThomasMark I Rees
Jun 26, 2014·Trends in Pharmacological Sciences·Robert J VandenbergMacdonald J Christie
Feb 21, 2014·Histochemistry and Cell Biology·Kristof NotelaersJohan Hofkens
Jun 22, 2014·Brain : a Journal of Neurology·Alexander Carvajal-GonzálezAngela Vincent
Oct 16, 2014·BioMed Research International·Ahmed MaherHans-Georg Breitinger
Sep 23, 2011·Acta Neuropathologica·Andrew McKeon, Sean J Pittock
May 1, 2010·Neurochemical Research·Tatyana V Waseem, Sergei V Fedorovich
Aug 12, 2010·Pharmaceuticals·Yongchang ChangPaul Whiteaker
Nov 19, 2015·Annals of Neurology·Irene LeckerBeverley A Orser
Apr 4, 2015·Neuropharmacology·Sahil Talwar, Joseph W Lynch
Jan 26, 2016·Nature Reviews. Neuroscience·Sarah J CrispAngela Vincent

❮ Previous
Next ❯

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