Natriuretic and phosphaturic response to diuretics after parathyroidectomy in dogs

European Journal of Pharmacology
J G KleinmanW Flamenbaum

Abstract

Intact and acutely parathyroidectomized (TPTX) dogs were studied during hydropenia, volume expansion (VE), volume expansion plus ethacrynic acid (EA), and volume expansion plus acetazolamide (AZ). In intact dogs, VE produced marked increases in both Na+ and phosphate (Pi) excretion; in TPTX dogs, Na+ excretion increased but phosphaturia was minimal. Addition of EA increased Na+ but not Pi excretion in both groups. Discontinuing EA and substituting AZ in intact dogs produced a marked increase in Pi excretion compared to both VE and VE + EA. In TPTX dogs, AZ failed to increase Pi excretion compared to VE alone. The results suggest that increased distal Pi absorption in acutely TPTX dogs is not associated with NaCl reabsorption in the thick ascending loop of Henle or may occur at an alternative nephron site. Furthermore, the increased distal Pi reabsorptive capacity revealed by TPTX can overcome the increased distal Pi delivery produced by the superimposition of AZ on VE.

References

Nov 1, 1973·Kidney International·M Burg, N Green
Apr 1, 1973·Kidney International·L GradowskaE Slatopolsky
Oct 1, 1968·Metabolism: Clinical and Experimental·C G Duarte
Jul 1, 1969·The Journal of Clinical Investigation·S G MassryC R Kleeman
Aug 1, 1964·The Journal of Clinical Investigation·J C STRICKLERG GIEBISCH

Related Concepts

Acetazolamide Sodium, (Sterile)
Metazoa
Canis familiaris
Hydromedin
Hemodynamics
Natriuresis
Parathyroid Gland
Orthophosphate

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