Natriuretic efficiency of frusemide as a consequence of drug input rate

British Journal of Clinical Pharmacology
M WakelkampG Paintaud

Abstract

The aim of the present study was to investigate the influence of the rate of delivery of frusemide to its site of action on the effect and efficiency of the drug. Frusemide 30 mg was administered as a bolus dose, a slow-rate infusion and a bolus dose in combination with 2 g of probenecid in a three way cross-over design to seven healthy volunteers. Urinary volume and contents of frusemide and sodium were measured in samples collected over 10 h. Total natriuretic response was 40% higher (P < 0.001) after the infusion and 20% higher (P < 0.05) after the combined treatment with probenecid, as compared with the bolus dose. Total natriuretic efficiency did not differ between the infusion (0.013 mmol microg(-1)) and the combined treatment with probenecid (0.015 mmol microg(-1)), but was significantly higher as compared with the bolus dose (0.009 mmol microg(-1)). Natriuretic effect data were modeled according to the sigmoid Emax model and the frusemide excretion rate with maximum efficiency (ER(effmax)) was calculated from the estimated parameters. For both the frusemide infusion and the combined treatment with probenecid, the time course of delivery of frusemide into the urine consistently approached ER(effmax) more closely than was...Continue Reading

Citations

Nov 25, 2003·BMJ : British Medical Journal·J K Aronson, R E Ferner
Nov 15, 2006·Journal of Clinical Pharmacology·Stig StridAnders Grahnén
Oct 24, 2013·Biopharmaceutics & Drug Disposition·Scott A Van WartDonald E Mager
Mar 18, 2000·Canadian Journal of Physiology and Pharmacology·G Castañeda-Hernández, V Granados-Soto
Dec 2, 1998·British Journal of Clinical Pharmacology·M WakelkampJ Gabrielsson
Oct 6, 1999·British Journal of Clinical Pharmacology·M WakelkampC Graffner

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