PMID: 6539464Mar 1, 1984Paper

Natriuretic factor exerts a ouabain-like activity in the rat colon in vitro

Pflügers Archiv : European journal of physiology
B Martin, H Favre

Abstract

A previously described natriuretic factor (NF) found in urine from man receiving a high salt diet has been postulated to be of hormonal nature. This factor inhibits Na-K ATPase and binds to ouabain receptors. In order to investigate if NF exerts its physiological activity through the Na-K ouabain sensitive pump, its capacity for inhibiting sodium transport has been tested in an in vitro rat colon preparation. Colonic mucosa from rats fed 0.55, 3.55, and 6.55 mmol Na a day were mounted in an Ussing chamber. Inhibition of short-circuit current (SCC) and PD was observed only when NF was added to the serosal side of the membrane and was similar to that observed with ouabain. In rats fed a low or normal salt diet, inhibition of SCC and PD starts after a lag period of 10 min and reaches its maximum inhibition (about 60%) after 90 min. By contrast colonic mucosa from rats receiving a high salt diet exhibits a higher SCC and PD (basal values) and inhibition of the sodium transport starts immediately after addition of NF to the bathing solution. The data demonstrate the similarity of physiological action of ouabain and natriuretic factor on the sodium transport by the colon in vitro. Experiments with rats receiving a high salt diet sugg...Continue Reading

References

Oct 1, 1979·Pflügers Archiv : European journal of physiology·H FavreM Gourjon
Jul 1, 1977·Clinical Science and Molecular Medicine·H E De Wardener
Dec 15, 1978·Pflügers Archiv : European journal of physiology·M Fromm, U Hegel
Nov 1, 1975·The Journal of Clinical Investigation·H FavreJ J Bourgoignie
Nov 1, 1973·The American Journal of Physiology·H J Binder, C L Rawlins
Jan 1, 1982·American Journal of Industrial Medicine·A W MuskC B Monroe
Feb 1, 1952·The American Journal of Physiology·E F ADOLPH, J P NORTHROP

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Citations

Jan 1, 1986·Critical Reviews in Clinical Laboratory Sciences·S W Graves

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