PMID: 9184848Apr 1, 1997Paper

Natriuretic peptide immunoreactivity in nerve structures and Purkinje fibres of human, pig and sheep hearts

The Histochemical Journal
M HanssonS Forsgren

Abstract

Atrial natriuretic peptide is a well-described peptide in cardiac Purkinje fibres and has been shown to interfere with the autonomic regulation in the heart of various species, including man. Recently, we detected immunoreactivity for the peptide in intracardial ganglionic cells and nerve fibre varicosities of bovine hearts, by the use of a modified immunostaining technique that induced an improved detection of natriuretic peptides. These findings raised the question as to whether natriuretic peptides are detectable in these tissues in man and other species. The conduction system from human, pig and sheep hearts was dissected processed with antisera against atrial natriuretic peptide and the closely related brain natriuretic peptide. Immunostaining for the brain natriuretic peptide was detected in some Purkinje fibres in all of these species. Interestingly, in pig, sheep and human hearts, some ganglionic cells and nerve fibres showed atrial natriuretic peptide immunoreactivity, particularly in the soma of human ganglionic cells. This is the first study showing immunoreactivity for the atrial natriuretic peptide in nerve structures and for the brain natriuretic peptide in Purkinje fibres of the human heart. The results give a mo...Continue Reading

Citations

Sep 13, 2002·Microscopy Research and Technique·Magnus Hansson
Aug 3, 2004·Microscopy Research and Technique·Magnus Hansson, Sture Forsgren
Oct 18, 2005·Microscopy Research and Technique·Simon Lundberg, Magnus Hansson
Mar 10, 2001·Biological Research for Nursing·S D Kim, M R Piano
Sep 6, 2002·Oncogene·M Christine Hollander, Albert J Fornace
Apr 26, 2007·International Urology and Nephrology·M Cagatay TaskapanHulya Taskapan
Dec 28, 2005·Biochemical and Biophysical Research Communications·Essam Mohamed AbdelalimRyuzo Torii
Jan 16, 2007·The Journal of Hand Surgery·Elisabet HagertBjörn-Ove Ljung

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