Natriuretic peptide receptors A and B have different cellular distributions in rat kidney

Kidney International
D RitterJ E Greenwald

Abstract

The cellular distribution of guanylyl cyclase coupled natriuretic peptide receptors type A (GC-A) and type B (GC-B) was examined by immunocytochemistry in normal rat kidney, and compared with the distribution of the vacuolar H(+)-ATPase. Staining for GC-A was found in glomeruli, thin limbs of Henle's loop, cortical collecting tubule, and inner medullary collecting duct. Staining for GC-B was found in glomeruli and the same nephron sections as GC-A, with the exception of the thin limbs. In the cortical collecting tubule, GC-A was found in both principal and intercalated cells; GC-B was restricted to the apical pole of alpha intercalated cells. In inner medullary collecting duct cells, GC-A was located on the basal membrane, whereas GC-B was found in the apical pole. The different pattern of polarization of natriuretic peptide receptors in the inner medulla provides a plausible basis for the different physiologic effects of atrial natriuretic factor and C-type natriuretic peptide. The results also suggest the possibility that GC-B is involved in the regulation of bicarbonate transport in the cortical collecting tubule.

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Citations

Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·T J SoaresJ Antunes-Rodrigues
Jun 2, 2012·Journal of the American Society of Nephrology : JASN·Yoshihisa OgawaKazuwa Nakao
Jul 27, 1999·General and Comparative Endocrinology·S K MeierJ A Donald
Jun 28, 2008·Journal of the American College of Cardiology·Ondrej LisyJohn C Burnett
Sep 17, 2016·Scientifica·N L Rukavina MikusicM R Choi
Apr 4, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Y HuR Semba
May 8, 2016·Journal of the American Society of Nephrology : JASN·Janina StaffelFrank Schweda
Apr 18, 2001·Cellular Signalling·M Silberbach, C T Roberts

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