Natriuretic peptide receptors in human artery and vein and rabbit vein graft

Hypertension
T IkedaT Ban

Abstract

Natriuretic peptides elicit their biological effects by elevation of cGMP through activation of two biologically active receptors: natriuretic peptide A receptor, which shows high affinity to atrial and brain natriuretic peptides, and natriuretic peptide B receptor, which is specific to C-type natriuretic peptide. To elucidate the implications of the natriuretic peptide system in arteries and veins, we examined the cGMP production in response to atrial and C-type natriuretic peptide and gene expressions of biologically active natriuretic peptide receptors in human gastroepiploic artery, internal mammary artery, and saphenous vein. Atrial natriuretic peptide augmented cGMP production more potently by one order of magnitude in arteries than in veins. C-type natriuretic peptide stimulated cGMP production weakly and equally in these vessels. Analyzed by reverse transcription-polymerase chain reaction, gene expression of natriuretic peptide A receptor was four times more abundant in arteries than in veins. Gene expression of natriuretic peptide B receptor was approximately the same between these vessels. We also studied the responsiveness to atrial and C-type natriuretic peptide in rabbit jugular vein grafted into carotid artery. In...Continue Reading

References

Jun 28, 1991·Biochemical and Biophysical Research Communications·M FuruyaH Matsuo
Aug 1, 1991·Endocrinology·Y KomatsuN Hama
Jul 16, 1990·Biochemical and Biophysical Research Communications·M FuruyaH Matsuo
Jan 1, 1993·The American Journal of Physiology·R V Sharma, R C Bhalla

❮ Previous
Next ❯

Citations

Mar 25, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·J BonattiB Puschendorf
Feb 27, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·K L Minerds, J A Donald
Jun 16, 2001·British Journal of Pharmacology·K E Wiley, A P Davenport
Oct 8, 2004·Critical Care : the Official Journal of the Critical Care Forum·Rochus Witthaut
Feb 11, 2014·The Journal of Thoracic and Cardiovascular Surgery·Motoaki OhnakaRyuzo Sakata
May 25, 2005·Peptides·Stephanie Schulz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.