Natriuretic peptide receptors in the human endolymphatic sac

Archives of Otolaryngology--head & Neck Surgery
John L DornhofferShulin Li

Abstract

To examine human endolymphatic sac (ELS) tissue for atrial natriuretic peptide (ANP) receptor subtypes A, B, and C. Pilot study. Immunohistochemical analysis of human ELS tissue specimens. The ANP receptors were characterized using the peroxidase/antiperoxidase method and polyclonal antibodies directed against each receptor subtype. The identity of the stain regarding receptor subclass was masked from the observer. Human kidney tissue known to contain all 3 receptor subtypes was used as a control. Presence of the receptor subclasses was confirmed using reverse transcriptase-polymerase chain reaction (RT-PCR) techniques. Samples of ELS tissue were obtained at autopsy from 3 fresh cadaver specimens (6 ears) and as surgical specimens from 3 patients (1 for immunohistochemical analysis and 2 for RT-PCR) undergoing acoustic neuroma resection using the translabyrinthine approach. The ANP type B receptors demonstrated moderate to strong reactivity in all 7 specimens, and mild to moderate staining to the ANP type C receptor was also noted. No appreciable reactivity to the ANP type A receptor was detected using immunohistochemical techniques. All 3 receptor subclasses were detected using RT-PCR. The ANP receptors are found within the hu...Continue Reading

Citations

Jun 19, 2013·Acta Oto-laryngologica·Yasuhiro ChiharaDaniel J Brown
Apr 4, 2015·Chronobiology International·Alcione Botelho PereiraFernando Madalena Volpe
Jan 14, 2004·Kidney International·Hassane IzzedineGilbert Deray
Jan 25, 2006·Medical Hypotheses·Claudio BorghiAntonio Pirodda
Nov 27, 2002·The Annals of Otology, Rhinology, and Laryngology·John L DornhofferShulin Li
May 14, 2005·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Ryan T BooneJohn Dornhoffer
Mar 16, 2017·The Laryngoscope·Martin Nue MøllerPer Cayé-Thomasen

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