Natriuretic peptide testing in clinical medicine

Cardiology in Review
Shafiq Rehman, James L Januzzi

Abstract

Since the discovery of atrial natriuretic factor in 1981 by de Bold et al, there has been tremendous progress in our understanding of natriuretic peptides (NPs). Recently, testing for brain-type NP (BNP) and its amino terminal cleavage equivalent (NT-proBNP) has been rapidly adopted in clinical medicine for numerous indications, including the diagnosis and exclusion of heart failure (HF). In this regard, logical application of BNP or NT-proBNP testing may not only reduce healthcare costs but also potentially reduce adverse clinical outcomes. With respect to this fact, the potential importance of the concentration of the NPs for prognosis and the response of BNP or NT-proBNP to therapeutic intervention in terms of clinical events has been demonstrated. On the basis of these observations it is reasonable to expect that concentrations of these peptides might be useful for the management of patients with HF, acting as a gauge of therapeutic accuracy and/or stability of disease. Besides HF, the prognostic utility of NPs has been explored in other settings, particularly in ischemic heart disease and those conditions that lead to right ventricular dysfunction.

References

Mar 3, 1988·Nature·T SudohH Matsuo
Feb 1, 1993·Journal of Hypertension·A M RichardsC Frampton
May 20, 1993·The New England Journal of Medicine·J E Parrillo
Jan 20, 1998·Lancet·T A McDonaghH J Dargie
May 18, 1999·European Heart Journal·S PriceT W Evans
Sep 19, 2000·Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology·R Latini, S Masson
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Q HeM C LaPointe
Oct 6, 2001·The New England Journal of Medicine·J A de LemosE Braunwald
Dec 12, 2001·Journal of the American College of Cardiology·J KoglinW vonScheidt
Jul 19, 2002·The New England Journal of Medicine·Alan S MaiselUNKNOWN Breathing Not Properly Multinational Study Investigators
Sep 7, 2002·JAMA : the Journal of the American Medical Association·Ramachandran S VasanDaniel Levy
Nov 13, 2002·Journal of the American College of Cardiology·Michel F RousseauUNKNOWN Belgian RALES Investigators
Dec 14, 2002·Circulation Research·Toshihiro TsurudaJohn C Burnett
Mar 4, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Peter A McCulloughUNKNOWN Breathing Not Properly Multinational Study Investigators
Mar 20, 2003·European Journal of Heart Failure·P JourdainD Duboc
May 6, 2003·The American Journal of Cardiology·Maria FrigerioRobert O Bonow
May 14, 2003·Circulation·Nils KucherSamuel Z Goldhaber

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Citations

Oct 11, 2014·Future Cardiology·Lori B Daniels, Antoni Bayes-Genis
Apr 21, 2009·Heart Failure Reviews·Kirkwood F AdamsChristopher M O'Connor
Jun 26, 2013·Expert Opinion on Medical Diagnostics·Domingo A Pascual-FigalAntonio Lax
Apr 14, 2009·Chest·José M PorcelAureli Esquerda
Jul 9, 2010·The Veterinary Clinics of North America. Small Animal Practice·Mark A Oyama, Gretchen E Singletary
Dec 29, 2009·Toxicology and Applied Pharmacology·Estelle Marrer, Frank Dieterle
Mar 26, 2009·Clinical Biochemistry·Barry McDonnellRichard O'Kennedy
Apr 13, 2011·Acta Anaesthesiologica Scandinavica·M OkkonenUNKNOWN FINNALI Study Group
Mar 19, 2016·Reproduction in Domestic Animals = Zuchthygiene·Mar FelicianoWrr Vicente
May 6, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Hong-Ling YangCheng Zhou
Jul 21, 2012·Journal of the American College of Cardiology·Alan S Maisel, Lori B Daniels

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