Natriuretic Peptides in Kawasaki Disease: the Myocardial Perspective

Diagnostics
Nagib Dahdah, Anne Fournier

Abstract

Making a diagnosis of Kawasaki disease with certainty may be challenging, especially since the recognition of cases with incomplete diagnostic criteria and its consequences. In order to build the diagnostic case in daily practice, clinicians rely on clinical criteria established over four decades ago, aided by non specific laboratory tests, and above all inspired by experience. We have recently studied the diagnostic value of N-terminal pro B-type natriuretic peptide to improve the diagnostic certainty of cases with complete or incomplete clinical criteria. Our working hypothesis was based on the fact that myocarditis is present in nearly all Kawasaki disease patients supported by histology data. In this paper, we review these facts and the myocardial perspective from the diagnostic and the mechanistic standpoints.

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Citations

Mar 23, 2019·Biomarkers in Medicine·Moises Rodriguez-GonzalezHelena M Cascales-Poyatos
Oct 28, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Kenichiro MiuraAkira Oka
Aug 31, 2021·European Journal of Pediatrics·Carlos D GrasaCristina Calvo

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BETA
biopsy

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